Ibuprofen-containing softgels
DCFirst Claim
Patent Images
1. A liquid softgel fill formulation consisting essentially of:
- a) greater than 30% by weight ibuprofen in free acid form in solution;
b) from about 30 to about 60% by weight polyethylene glycol;
c) from about 10 to about 30% by weight of polyvinylpyrrolidone; and
d) from about 1 to about 10% by weight of a surfactant.
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Abstract
Liquid softgel fill formulations containing ibuprofen in free acid form, and softgel capsules comprised of a gelatin sheath enclosing such fill formulations, are prepared by dissolving more than 30% of ibuprofen in free acid form in polyethylene glycol and at least 10% by weight of a polyvinylpyrrolidone having an average molecular weight of from about 2,000 to about 54,000. The formulations may also include a surfactant to increase the bioavailability of the ibuprofen.
58 Citations
26 Claims
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1. A liquid softgel fill formulation consisting essentially of:
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a) greater than 30% by weight ibuprofen in free acid form in solution;
b) from about 30 to about 60% by weight polyethylene glycol;
c) from about 10 to about 30% by weight of polyvinylpyrrolidone; and
d) from about 1 to about 10% by weight of a surfactant. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A liquid softgel fill formulation consisting essentially of:
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a) greater than 30% by weight ibuprofen in free acid form in solution;
b) from about 30 to about 60% by weight of polyethylene glycol having an average molecular weight of from about 200 to about 1,000;
c) from about 10 to about 30% by weight of polyvinylpyrrolidone having an average molecular weight of from about 2,000 to about 54,000; and
d) from about 1 to about 10% by weight of a surfactant to increase the bioavailability of said ibuprofen. - View Dependent Claims (9, 10)
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11. A softgel capsule comprised of a sheath enclosing a liquid fill, said fill consisting essentially of:
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a) greater than 30% by weight ibuprofen in free acid form in solution;
b) from about 30 to about 60% by weight polyethylene glycol;
c) from about 10 to about 30% by weight polyvinylpyrrolidone; and
d) from about 1 to about 10% by weight of a surfactant. - View Dependent Claims (12, 13, 14, 15, 16, 17)
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18. A softgel capsule comprised of a sheath enclosing a liquid fill, said fill consisting essentially of:
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a) at least 35% by weight ibuprofen in free acid form in solution;
b) from about 30 to about 50% by weight polyethylene glycol having an average molecular weight of from about 200 to about 1,000;
c) from about 15 to about 30% by weight of polyvinylpyrrolidone having an average molecular weight of from about 2,000 to about 11,000; and
d) a surfactant to increase the bioavailability of said ibuprofen. - View Dependent Claims (19, 20, 21, 22)
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23. A liquid softgel fill formulation consisting essentially of:
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a) greater than 30% by weight ibuprofen in free acid form in solution;
b) from about 30 to about 60% by weight polyethylene glycol;
d) from about 10 to about 30% by weight of polyvinylpyrrolidone, wherein the ratio of polyethylene glycol to polyvinylpyrrolidone less than about 2.5;
1; and
d) a surfactant to increase the bioavailability of said ibuprofen. - View Dependent Claims (24)
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25. A softgel capsule comprised of a sheath enclosing a liquid fill, said fill consisting essentially of:
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a) greater than 30% by weight ibuprofen in free acid form in solution;
b) from about 30 to about 60% by weight polyethylene glycol;
c) from about 10 to about 30% by weight polyvinylpyrrolidone, wherein the ratio of polyethylene glycol to polyvinylpyrrolidone is less than about 2.5;
1; and
d) a surfactant to increase the bioavailability of said ibuprofen. - View Dependent Claims (26)
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Specification