Osmotically stabilized microbubble preparations

  • US 6,258,339 B1
  • Filed: 05/05/1997
  • Issued: 07/10/2001
  • Est. Priority Date: 07/30/1993
  • Status: Expired due to Term
First Claim
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1. A microbubble preparation comprising an aqueous medium having dispersed therein a plurality of osmotically stabilized microbubbles, said microbubbles comprising:

  • a generally spherical microbubble membrane containing at least one nonfluorocarbon modifier gas and at least one gas osmotic agent, wherein said modifier gas and said oas osmotic aoent are present in a molar ratio from about 1;

    100 to about 1,000;

    1 wherein said ratio is effective to stabilize said microbubble preparation, with the proviso that said modifier gas is not water vapor, and wherein said gas osmotic agent is selected from the group consisting of perfluoropentane, perfluorocyclopentane, perfluoromethylcyclopentane, perfluorodimethylcyclobutane, perfluorohexane, perfluorocyclohexane, perfluoroheptane, perfluorocycloheptane, perfluoromethylcyclohexane, perfluorodimethylcyclopentane, perfluorotrimethylcyclobutane, perfluorotriethylamine and combinations thereof.

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