Transdermal drug patch with attached pocket for controlled heating device

• US 6,261,595 B1
• Filed: 02/29/2000
• Issued: 07/17/2001
• Est. Priority Date: 02/29/2000
• Status: Expired due to Fees

• Current Assignee: Zars, Inc.
• Original Assignee: Zars, Inc.
• Inventors: Rigby, Larry, Stanley, Theodore, Hull, Wade
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): GHALI, ISIS A D
• Application Number:
  US09/515,722
• Time in Patent Office: 504 Days
• Field of Search: 424/449, 424/447, 604/20
• US Class Current: 424/449
• CPC Class Codes: A61K 9/7084 Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
• CPC Class Codes: A61M 2037/0007 having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
• CPC Class Codes: A61M 35/00 Devices for applying media, e.g. remedies, on the human body devices for handling toiletry or cosmetic substances A45D; absorbent pads, e.g. swabs, A61F13/15
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

The present invention relates to a transdermal drug delivery system comprising a dermal drug delivery patch and a heating element compartment securable to the dermal drug delivery patch. A freely transferrable heating element is securable within the heating element compartment. A drug can be administered transdermally using the present invention by placing the dermal drug delivery patch upon a patient'"'"'s skin at an administration site. A heating element compartment is secured to the dermal drug delivery patch and a freely transferrable heating element is placed within the heating element compartment. The heating element provides controlled heat to the dermal drug patch and the patient'"'"'s skin aid thereby improves dermal drug administration.

Claims

1. A transdermal drug delivery system comprising:

a dermal drug delivery patch;

a heating element compartment securable to the dermal drug delivery patch; and

an exchangeable heating element for providing heat securable within the heating element compartment.

2. The drug delivery system of claim 1, wherein said heating element compartment is defined by a top side of said compartment being sufficiently sealed to a bottom side of said compartment to retain said heating element.

3. The drug delivery system of claim 1, wherein said heating compartment is defined by a top having at least a portion of one edge scaled to dermal drug delivery patch.

4. The drug delivery system of claim 1, wherein said heating element compartment further comprises a top having at least one opening for permitting oxygen to flow into said heating element compartment.

5. The drug delivery system of claim 1, wherein said heating element compartment defines an entry for freely transferring said heating element into and out of said heating element compartment.

6. The drug delivery system of claim 1, wherein said heating element compartment provides an area for restraining said heating element.

7. The drug delivery system of claim 1, wherein said heating element is retained within said compartment using tension.

8. The drug delivery system of claim 1, wherein said heating element is retained within said compartment using friction.

9. The drug delivery system of claim 1, wherein said heating element is retained within said compartment using an attachment clip.

10. The drug delivery system of claim 1, wherein said heating element is retained within said compartment using a very light adhesive for preventing lateral movement.

11. The drug delivery system of claim 1, wherein said top of said heating compartment provides at least one sealed edge for containing said heating element within said compartment.

12. The drug delivery system of claim 1, wherein said heating element provides heat using an oxidation reaction within said heating element.

13. The drug delivery system of claim 1, wherein said heating element corresponds in size and shape to said heating element compartment.

14. The drug delivery system of claim 1, wherein said heating element provides controlled heat.

15. The drug delivery system of claim 1, wherein said heating element is an electric heating element having an electronic control mechanism.

16. The drug delivery system of claim 1 wherein said heating element is designed to provide insulative properties to the drug delivery system.

17. The drug delivery system of claim 1, wherein said heating element is an onset heating element for providing heat to improve the onset time of a drug delivery regimen.

18. The drug delivery system of claim 1, wherein said heating element is a breakthrough pain heating element for providing heat to improve drug delivery in a treatment of breakthrough pain.

19. The drug delivery system of claim 1, wherein said heating element is a breakthrough craving heating element for providing heat to improve drug delivery in a treatment of breakthrough craving.

20. The drug delivery system of claim 1, wherein said heating element is a steady state heating element for providing heat to improve a steady state drug delivery regimen.

21. The drug delivery system of claim 1, wherein said heating element is a breakthrough effect heating element.

22. A method for delivering a drug transdermally comprising the steps of:

placing a dermal drug delivery patch upon a patient'"'"'s skin at an administration site;

securing a heating element compartment to said dermal drug delivery patch; and

disposing an exchangeable heating element for providing heat within the heating element compartment.

23. The method of claim 22, wherein said heating element compartment is defined by a top having at least one edge sealed to a bottom.

24. The method of claim 22, wherein said heating compartment defined by a top having at least a portion of one edge sealed to the dermal drug delivery patch.

25. The method of claim 22, wherein said heating element compartment further comprises a top having at least one opening for permitting oxygen to flow into said heating element compartment.

26. The method of claim 22, wherein said heating element compartment defines an entry for freely transferring said heating element into and out of said heating element compartment.

27. The method of claim 22, wherein said heating element compartment provides an area for restraining said heating element.

28. The method of claim 22, wherein said heating element is retained within said compartment using tension.

29. The method of claim 22, wherein said heating element is retained within said compartment using friction.

30. The method of claim 22 wherein said heating element is retained within said compartment using an attachment clip.

31. The method of claim 22, wherein said heating element is retained within said compartment using a very light adhesive for preventing lateral movement.

32. The method of claim 22, wherein said top of said heating compartment provides at least one sealed edge for containing said heating element within said compartment.

33. The method of claim 22, wherein said heating element provides beat using an oxidation reaction within said heating element.

34. The method of claim 22, wherein said heating element corresponds in size and shape to said heating element compartment.

35. The method of claim 22, wherein said heating element provides controlled heat.

36. The method of claim 22, wherein said heating element is an electric heating element having an electronic control mechanism.

37. The method of claim 22, wherein said heating element is designed to provide insulative properties to the drug delivery system.

38. The drug delivery system of claim 22, wherein said heating element is an onset heating element for providing heat to improve the onset time of a drug delivery regimen.

39. The drug delivery system of claim 22, wherein said heating element is a breakthrough pain heating element for providing heat to improve drug delivery in a treatment of breakthrough pain.

40. The drug delivery system of claim 22, wherein said heating element is a breakthrough craving heating element for providing heat to improve drug delivery in a treatment of breakthrough craving.

41. The drug delivery system of claim 22, wherein said heating element is a steady state heating element for providing heat to improve a steady state of a drug delivery regimen.

42. The method of claim 22, wherein said heating element is a breakthrough effect heating element.

43. The method of claim 22, further comprising the steps of removing said heating element from the heating element compartment and replacing said heating element with a freely transferrable second heating element in the heating element compartment.

44. The method of claim 43, further comprising the steps of heating said dermal drug delivery patch and the skin of a patient with said second heating element to provide faster onset.

45. The method of claim 43, further comprising the steps of heating said dermal drug delivery patch and the skin of a patient with said second heating element to provide relief from breakthrough pain.

46. The method of claim 43, further comprising the steps of heating said dermal drug delivery patch and the skin of a patient with said second heating element to provide relief from breakthrough cravings.

47. The method of claim 43, further comprising the steps of heating said dermal drug delivery patch and the skin of a patient with said second heating element to provide relief from breakthrough effects.

48. The method of claim 43, further comprising the steps of heating said dermal drug delivery patch and the skin of a patient with said second heating element to provide deeper drug penetration.

49. The method of claim 43, further comprising the steps of heating said dermal drug delivery patch and the skin of a patient with said second heating element to provide drug serum concentration levels that mimic a patient'"'"'s circadian period.

50. A method for delivering a drug transdermally comprising the steps of:

placing a dermal drug delivery patch upon a patient'"'"'s skin at an administration site;

securing a cooling element compartment to said dermal drug delivery patch; and

disposing a exchangeable cooling element within the cooling element compartment.

51. A method for delivering a drug transdermally comprising the steps of:

placing a dermal drug delivery patch upon a patient'"'"'s skin at an administration site;

securing an iontophoresis device compartment to said dermal drug delivery patch; and

disposing an iontophoresis device within the iontophoresis compartment.

52. A method for transdermally delivering a drug comprising the steps of:

securing a heating element structure on a patient'"'"'s skin, said heating element structure comprising a heating element disposed above the patient'"'"'s skin and defining a drug patch compartment; and

disposing a dermal drug patch within said drug patch compartment, said drug patch being proximate to and capable of being heated by said heating element, and said drug patch being exchangeable into and out of the drug patch compartment.