Inhibitors of protein isoprenyl transferases

  • US 6,277,871 B1
  • Filed: 11/18/1999
  • Issued: 08/21/2001
  • Est. Priority Date: 11/20/1998
  • Status: Expired due to Fees
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First Claim
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1. A compound of Formula I or a pharmaceutically acceptable salt thereof, whereL1 is selected from (1) phenyl, (2) naphthyl, (3) dihydronaphthyl, and (4) tetrahydronaphthyl,  

  • where (1)-(4) can be optionally substituted with 1 or 2 substituents independently selected from (a) alkyl, (b) halogen, (c) perfluoroalkyl, and (d) —

    OR3 where R3 is selected from (a) hydrogen and (b) alkyl;

    R1 is hydrogen;

    R2 is selected from (1) alkyl where the alkyl can be optionally substituted with 1, 2, or 3 substituents independently selected from (a) —

    CO2R4 where R4 is selected from (i) hydrogen, (ii) alkyl, and (iii) a carboxy-protecting group  

    and (b) —

    S(O)tR7, where R7 is selected from (i) hydrogen, (ii) alkyl, and (iii) aryl, andZ is —

    C(O)R12 where R12 is  

    where R16 is alkyl, where the alkyl is substituted with 1, 2, or 3 cycloalkyl substituents.

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