Controlled fluid transfer system

• US 6,280,408 B1
• Filed: 04/05/1999
• Issued: 08/28/2001
• Est. Priority Date: 11/09/1992
• Status: Expired due to Fees

• Current Assignee: Anatole J. Sipin
• Original Assignee: Anatole J. Sipin
• Inventors: Sipin, Anatole J.
• Primary Examiner(s): Kennedy, Sharon
• Assistant Examiner(s): Lam, Ann Y.
• Application Number:
  US09/286,400
• Time in Patent Office: 876 Days
• Field of Search: 604/65, 604/66, 604/67, 604/132, 604/133, 604/140, 604/141, 604/142, 604/145, 604/146, 604/151, 604/153, 222/15, 222/55, 222/96
• US Class Current: 604/65
• CPC Class Codes: A61M 5/1483 using flexible bags externally pressurised by fluid pressure
• CPC Class Codes: A61M 5/16886 for measuring fluid flow rate, i.e. flowmeters
• CPC Class Codes: A61M 5/365 Air detectors A61M5/1684 takes precedence; in extracorporeal blood circuits A61M1/3626

Abstract

The present invention is a closed loop system for transfer of a fluid through a line between a reservoir and a vessel in a manner to provide a flow-related parameter at a selected value. The system will have major use as a non-gravity-dependent infusion device. The system comprises a pressurizable reservoir containing a quantity of the fluid; means to control the flow of the fluid being transferred in a conduit between the reservoir and the vessel, including means to pressurize the reservoir; reference means with an output related to a selectable value of the flow-related parameter; means to measure the flow-related parameter; means to compare the outputs of the reference means and the measuring means; and means responsive to the output of the comparator means to adjust the fluid flow control means to provide the selected value of the flow-related parameter. Normally, the flow-related parameter will be the fluid flow rate in the conduit or the change of fluid volume in the reservoir.

Claims

1. A system for controlled transfer of at least two fluids through lines between at least two reservoirs and a vessel in a manner to provide respective flow-related parameters at selected values, comprising:

(a) a first pressurizable reservoir to contain a quantity of said first fluid;

(b) a fluid vessel to contain a different quantity of said first fluid;

(c) a first conduit means connected at one end to said first reservoir and at the other end to said vessel, to transfer said first fluid between them;

(d) means to control the flow of said first fluid in said first conduit, including means to pressurize said first reservoir in a positive or negative sense with respect to atmospheric pressure, to provide a pressure difference between between said first reservoir and said vessel, that will cause fluid to flow in either direction through said first conduit between said first reservoir and said vessel, depending on the sense of the pressure difference;

(e) first reference means to provide an electrical signal related to a selectable value of a flow related parameter for said first fluid;

(f) first means to provide an electrical signal related to the measured value of said flow-related parameter for said first fluid;

(g) first means to compare the electrical signal outputs of said first reference means and said first flow-related parameter measuring means, and to provide an electrical signal output related to their difference;

(h) means, including a microcomputer, responsive to said electrical signal output of said first comparator means to adjust said first fluid flow control means, in a direction and with a magnitude to provide the selected value of said first flow-related parameter;

(i) a second pressurizable reservoir to contain a quantity of a second fluid;

(j) a second conduit means connected at one end to said second reservoir and at the other end to said vessel to transfer said second fluid between said second reservoir and said vessel;

(k) means to control said second fluid in said second conduit means, including means to pressurize said second reservoir;

(l) second reference means to provide an electrical signal related to a selectable value of a flow-related parameter for said second fluid;

(m) second measuring means to provide an electrical signal related to the measured value of said flow-related parameter for said second flank;

(n) second comparator means to compare the electrical signal outputs of said second reference means and said second measuring means, and to provide an electrical signal output related to their difference; and

(o) means including a microcomputer, responsive to said electrical signal output of said second comparator means to adjust said second fluid control means in a direction and with a magnitude to provide the selected value of said second flow-related parameter.

2. A controlled fluid transfer system as claimed in claim 1, in which one of said fluid reservoirs is a container with at least one flexible wall, and said reservoir pressurizing means is a pressure applicator with a pneumatically-actuated movable wall in contact with a flexible wall of said container, said pressure applicator being connected to a source of variable pressure that applies to the fluid in said container through said movable wall of said pressure applicator and said flexible wall of said container.

3. A controlled fluid transfer system as claimed in claim 1, in which said pressurizing means for at least one of said reservoirs include a sealed, relatively rigid housing, a source of variable pneumatic pressure, a pneumatic pressurizing port in the wall of said housing pressurizing port, to transfer pressurizing gas between said pneumatic pressure source and the interior of said housing, and in which said reservoir is a container with at least one movable wall, located in the interior of said housing and connected to said fluid transfer conduit means, through a seal in the wall of said housing, so as to cause flow of fluid through said fluid transfer conduit means from said reservoir to said vessel, when said variable pneumatic pressure is positive, and to cause flow of fluid through said fluid transfer conduit means from said vessel to said reservoir when said variable pneumatic pressure is negative.

4. A controlled fluid transfer system as claimed in claim 1, in which one of said flow-related parameters is the fluid flow rate in the corresponding conduit means and said flow-related parameter measuring means include means, having an output, to measure the rate of said fluid through said conduit means.

5. A controlled fluid transfer system as claimed in claim 1, in which one of said flow related parameters is the change of fluid volume in one of said reservoirs.

6. A controlled fluid transfer system as claimed in claim 4, in which said fluid flow rate measuring means include a measuring restrictor in said fluid flow conduit means and a transducer with an electrical output related to the fluid pressure drop across said restrictor as a measure of the flow rate of said fluid.

7. A controlled fluid transfer system as claimed in claim 1, in which one of said flow control means include adjustable valve means in the corresponding conduit means to vary the resistance to flow of said fluid between said reservoir and said vessel.

8. A controlled fluid transfer system as claimed in claim 1, in which one of said reservoir pressurizing means are adjusted to provide the selected value of the corresponding flow-related parameter.

9. A controlled fluid transfer system as claimed in claim 1, in which said valve means are adjusted to provide the selected value of said flow-related parameter.

10. A controlled fluid transfer system as claimed in claim 9, in which one of said reservoir pressurizing means are adjusted to maintain the pressure of said reservoir at a constant selected value.

11. A controlled fluid transfer system as claimed in claim 3, in which one of said fluid control means include control means include adjustable valve means in the corresponding means to vary the resistance to flow of said fluid between said reservoir and said vessel, said valve means are adjusted to maintain the pneumatic pressure in the interior of said housing at a constant selected value, and said source of variable pneumatic pressure is adjusted to maintain the pneumatic mass rate of flow in said gas transfer line between said source and the interior of said housing and through said port at a constant value required to maintain the flow rate of fluid in said conduit means between said reservoir and said vessel at the selected value.

12. A controlled fluid transfer system as claimed in claim 3, in which at least one of said fluid control means include a restriction in said fluid transfer conduit means between said reservoir and said vessel, means to activate said source of variable pneumatic pressure when said pneumatic pressure in the interior of said housing reaches a lower limit value of a positive or a negative sense, to provide gas flow through said gas transfer line between said pneumatic pressure source and the interior of said housing, and to de-activate said pneumatic pressure source when said pneumatic pressure reaches an upper limit value, and means to sense the time for the pneumatic pressure to decay from said upper pressure limit to said lower pressure limit as a measure of the rate of flow of said fluid in said fluid in said fluid transfer conduit means between said reservoir and said vessel.

13. A controlled fluid transfer system as claimed in claim 3, in which at least one of said flow-related parameter means include means to measure the volumetric flow rate of said fluid in the corresponding fluid transfer conduit means;

said fluid flow rate measuring means, having an output, to measure the volumetric flow rate of the gas in said gas transfer line, at a location in said line where the rate of the gas in said gas transfer line, at a location in said line where the difference between the gas pressure at said flow rate measuring location and the gas pressure in the interior of said housing is small compared to their absolute value;

means, having an output, responsive to the outputs of said gas flow rate measuring means and said gas pressure measuring means to compute the volumetric flow rate of said fluid in said fluid transfer conduit means in accordance with the following equations;

$V_h=V_o+{\int <br><br>}_o^t<br><br>Q_f<br><br>\text{\hspace{1em}<br><br>}<br><br><br><br>t$

where Q_f is the computed volumetric flow rate of said fluid in said fluid transfer line, Q_L is the measured volumetric flow rate of the gas in said gas transfer line at said flow rate measuring locations, V_h is the volume occupied by the gas in said housing, exterior to said reservoir, P_g is the measured gas pressure, V_o is the residual volume occupied by the gas in said housing when said reservoir is full.

14. A controlled fluid transfer system as claimed in claim 13, including means, having an output, to compute the volume of said fluid transferred through the fluid transfer conduit means as the time integral of the computed field volumetric flow rate.

15. A controlled fluid transfer system as claimed in claim 13, in which said gas flow rate measuring means is a gas flow sensor in said gas transfer line, whose output is an electrical signal, said gas pressure measuring means is a gas pressure transducer whose output is an electrical signal, and said fluid flow rate computing means is a microcomputer, whose inputs are the electrical signal from said gas flow sensor, the electrical signal from said gas pressure transducer, and an initial electrical input proportional to the value of the residual gas volume in said housing.

16. A controlled fluid transfer system as claimed in claim 1, in which said fluid is liquid, including non-gravity-dependent means in each of said fluid transfer conduit means to effectively separate gas bubbles from said liquid flowing through said gas separating means in any orientation.

17. A controlled fluid transfer system as claimed in claim 1, in which said fluid is a liquid, including means in each of said fluid transfer conduit means to detect the passage of gas bubbles in said liquid flowing through said fluid transfer conduit means.