Refillable implantable drug delivery pump

• US 6,283,949 B1
• Filed: 12/27/1999
• Issued: 09/04/2001
• Est. Priority Date: 12/27/1999
• Status: Expired due to Term

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Roorda, Wouter Erik
• Primary Examiner(s): Nguyen, Anhtuan T.
• Application Number:
  US09/472,656
• Time in Patent Office: 617 Days
• Field of Search: 417/477.7, 417/477.11, 604/891.1, 604/890.1, 604/132, 604/133, 604/151, 604/153, 604/154, 604/288-1-2, 604/257, 128/DIG.12, 128/DIG.13
• US Class Current: 604/288.02
• CPC Class Codes: A61M 5/14232 Roller pumps
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: Y10S 128/12 Pressure infusion

Abstract

An implantable drug delivery pump includes a reservoir, a dispensing chamber adjacent to the reservoir, a dispensing passage provided along an interior surface of the dispensing chamber, and an actuator for applying a moving compressive force onto the dispensing passage. The pump is subcutaneously implantable in a patient, and a drug is injected into the reservoir through a septum provided on a housing for the reservoir. As the compressive force applied by the actuator moves along the dispensing passage, the drug preparation is simultaneously pushed out of the dispensing passage into a catheter for delivery to the desired site, and additional drug preparation is drawn into the dispensing passage from the reservoir. The actuator includes a rotating arm driven by an motor at a controllable rate.

Claims

1. An implantable drug delivery device, comprising:

a dispensing chamber having an upper surface, said dispensing chamber comprising;

a dispensing passage formed along an interior surface of said dispensing chamber and having an intake end and an outlet end; and

an actuator for applying to said dispensing passage a rotational compressive force moving in a direction from said intake end towards said outlet end; and

a reservoir housing provided adjacent said upper surface of said dispensing chamber and having a reservoir provided therein, said reservoir being in fluid communication with said intake end of said dispensing passage; and

means for filling said reservoir, wherein said means for filling is provided in relation to a surface of said reservoir housing which is not adjacent to said upper surface of said dispensing chamber.

2. The device of claim 1, wherein said reservoir housing has a footprint size approximately equal to an outer circumferential size of said dispensing chamber.

3. The device of claim 2, wherein said reservoir housing has a circular outer surface and said dispensing chamber has a circular outer surface coaxial with said circular outer surface of said reservoir housing.

4. The device of claim 1, further comprising a one-way intake valve formed at said intake end.

5. The device of claim 1, further comprising a one-way outlet valve formed at said outlet end.

6. The device of claim 1, wherein said actuator generates a plurality of compressive forces on said dispensing passage.

7. The device of claim 1, wherein said dispensing passage is a flexible tube.

8. The device of claim 1, further comprising a material provided between said reservoir and said reservoir housing to apply a compressive force onto said reservoir.

9. The device of claim 8, wherein said material is a liquid at low temperature and vaporizes at body temperature.

10. The device of claim 1, wherein said means for fill said reservoir includes a septum for filling said reservoir with fluid.

11. The device of claim 1, further comprising a catheter attached to said outlet end of said dispensing passage.

12. The device of claim 1, wherein said actuator applies said compressive force to compress said dispensing passage between said actuator and said interior portion of said dispensing chamber.

13. An implantable drug delivery device comprising:

a dispensing chamber having an upper surface, said dispensing chamber comprising;

a dispensing passage formed along an interior surface of said dispensing chamber and having an intake end and an outlet end, wherein said interior surface of said dispensing chamber is circular, whereby said dispensing passage is provided on a circular path along said interior surface; and

an actuator for applying to said dispensing passage a compressive force moving in a direction from said intake end towards said outlet end, said actuator comprising;

a rotatable compressor having an axis of rotation at a center of the circular path of said dispensing passage;

a contact member connected on an end of said rotatable compressor distal from said axis of rotation, said contact member generating said compressive force on said dispensing passage; and

a motor for rotating said rotatable compressor; and

a reservoir housing provided adjacent said upper surface of said dispensing chamber and having a reservoir provided therein, said reservoir being in fluid communication with said intake end of said dispensing passage.

14. The device of claim 13, wherein said contact member comprises a roller.

15. The device of claim 13, wherein said actuator further comprises a battery for generating power to said motor.

16. The device of claim 13, wherein said motor rotates said rotatable compressor at an adjustable rate.

17. The device of claim 13, wherein said dispensing passage is provided along said interior surface of said dispensing chamber such that said intake end is adjacent said outlet end.

18. A method for operating an implantable drug delivery device, comprising:

providing a dispensing chamber having an upper surface, an interior surface, and an outer circumferential surface;

providing a dispensing passage along an interior surface of a dispensing chamber, said dispensing passage having an intake end and an outlet end;

providing a reservoir filled with a fluid and in fluid communication with said intake end of said dispensing passage;

housing said reservoir in a reservoir housing adjacent to said upper surface of said dispensing chamber and having an outer circumferential surface concentric with said outer circumferential surface of said dispensing chamber;

applying a compressive force on said dispensing passage; and

moving said compressive force in a direction from said intake end towards said outlet end, thereby urging fluid contained between said compressive force and said outlet end out of said outlet end, and drawing fluid from said reservoir into said dispensing passage through said intake end.

19. The method of claim 18, further comprising injecting fluid into said reservoir.

20. The method of claim 18, wherein:

said providing said dispensing passage comprises providing said dispensing passage such that said dispensing passage traces a circular path along said interior portion of said dispensing chamber;

said applying said compressive force comprises providing a rotatable compressor having a contact member at one end, said compressor compressing said dispensing passage between said contact member and said interior portion of said dispensing chamber; and

said moving said compressive force comprises rotating said compressor about an axis of rotation at a center of said circular path, thereby moving said contact member along said dispensing passage in a direction from said intake end towards said outlet end.

21. The method of claim 18, further comprising inserting a material between said reservoir and said reservoir housing to apply a compressive force onto said reservoir.

22. The device of claim 21, wherein inserting said material between said reservoir and said reservoir housing comprises inserting a material which is a liquid at low temperature and a gas at body temperature.

23. An implantable drug delivery device, comprising:

a dispensing chamber having an upper surface, a round inner surface, and a round outer surface;

a reservoir adjacent to said upper surface of said dispensing chamber and having a round outer surface concentric with said round outer surface of said dispensing chamber;

a dispensing passage provided along a circular path on said round inner surface of said dispensing chamber, said dispensing passage having an intake end connected to said reservoir and an outlet end adjacent said intake end;

a rotatable arm rotatable about an axis of rotation located at a center of said circular path;

a contact member provided on an end of said rotatable arm distal to said axis of rotation, said contact member compressing said dispensing passage against said inner surface of said dispensing chamber; and

a motor for rotating said rotatable arm.

24. The device of claim 23, further comprising a catheter attached to aid outlet end.

25. The device of claim 23, further comprising a one-way intake valve provided at said intake end.

26. The device of claim 23, further comprising a one-way outlet valve provided at said outlet end.

27. An implantable drug delivery device, comprising:

a dispensing chamber having an upper surface, said dispensing chamber comprising;

a dispensing passage formed along an interior surface of said dispensing chamber and having an intake end and an outlet end; and

an actuator for applying to said dispensing passage a rotational compressive force moving in a direction from said intake end towards said outlet end; and

a reservoir housing provided adjacent said upper surface of said dispensing chamber and having a reservoir provided therein, said reservoir being in fluid communication with said intake end of said dispensing passage; and

a filling septum provided in relation to a surface of said reservoir housing which is not adjacent to said upper surface of said dispensing chamber.

28. The device of claim 27, wherein said reservoir housing has a footprint size approximately equal to an outer circumferential size of said dispensing chamber.

29. The device of claim 27, further comprising a material provided between said reservoir and said reservoir housing to apply a compressive force onto said reservoir.

30. The device of claim 27, wherein said dispensing passage is provided along said interior surface of said dispensing chamber such that said intake end is adjacent said outlet end.