Methods of imaging using osmotically stabilized microbubble preparations

  • US 6,287,539 B1
  • Filed: 05/05/1997
  • Issued: 09/11/2001
  • Est. Priority Date: 07/30/1993
  • Status: Expired due to Fees
First Claim
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1. A method of imaging an object, a body part or a body cavity comprising the steps of:

  • introducing into said object, body part or body cavity a microbubble preparation comprising an aqueous medium having dispersed therein a plurality of osmotically stabilized microbubbles, said microbubbles comprising a generally spherical microbubble membrane containing at least one modifier gas and at least one gas osmotic agent, wherein said modifier gas and said gas osmotic agent are present in a molar ratio from about 1;

    100 to about 1,000;

    1, wherein said ratio is effective to stabilize said microbubble preparation, with the proviso that said modifier gas is not water vapor, wherein said gas osmotic agent is selected from the group consisting of perfluoropentane, perfluorocyclopentane, perfluoromethylcyclopentane, perfluorodimethylcyclobutane, perfluorohexane, perfluorocyclohexane, perfluoroheptane, perfluorocycloheptane, perfluoromethylcyclohexane, perfluorodimethylcyclopentane, perfluorotrimethylcyclobutane, perfluorotriethylamine and combinations thereof; and

    imaging at least a portion of said object, body part or body cavity by ultrasound or magnetic resonance.

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