Separation by magnetic particles
First Claim
1. A method for separating at least one specific species of biological entities from a sample solution, said specific species constitute a first member of a pair forming group, the method comprising:
- (a) contacting the sample with a matrix of magnetic particles formed on a first substrate, the magnetic particles being coupled to at least one species of a second member of the pair forming group which specifically binds to said at least one species of biological entities;
(b) collecting magnetic particles from a desired location in the matrix; and
(c) rearranging the collected particles on another substrate in order to form a new matrix of magnetic particles.
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Abstract
The present invention concerns a method for separating at least one species of biological entities from a sample solution, by contacting the sample with a matrix of magnetic particles formed on a substrate such as a sheet a gel, etc. The particles in the matrix are coupled to entities capable of specifically binding to the species of biological entities to be separated. The separation is carried out either for detection purposes for obtaining separately each species of biological entities or for synthesis purposes. The invention further concerns matrices of magnetic particles formed on various substrates and kits for use in the method.
133 Citations
15 Claims
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1. A method for separating at least one specific species of biological entities from a sample solution, said specific species constitute a first member of a pair forming group, the method comprising:
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(a) contacting the sample with a matrix of magnetic particles formed on a first substrate, the magnetic particles being coupled to at least one species of a second member of the pair forming group which specifically binds to said at least one species of biological entities;
(b) collecting magnetic particles from a desired location in the matrix; and
(c) rearranging the collected particles on another substrate in order to form a new matrix of magnetic particles. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification