Polyester/cyanoacrylate tissue adhesive formulations

• US 6,299,631 B1
• Filed: 11/12/1999
• Issued: 10/09/2001
• Est. Priority Date: 11/12/1998
• Status: Expired due to Term

• Current Assignee: Poly-Med, Inc.
• Original Assignee: Poly-Med, Inc.
• Inventors: Shalaby, Shalaby W.
• Primary Examiner(s): Jackson, Gary
• Application Number:
  US09/439,167
• Time in Patent Office: 697 Days
• Field of Search: 606/213, 606/214, 524/460, 524/461, 526/298
• US Class Current: 606/214
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/11 for performing anastomosis; Buttons for anastomosis
• CPC Class Codes: A61L 24/043 Mixtures of macromolecular materials
• CPC Class Codes: C08L 35/04 Homopolymers or copolymers of nitriles C08L35/06, C08L35/08 take precedence
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

The present invention is directed to bioabsorbable adhesive/hemostatic formulations of a 2-alkoxyalkylcyanoacrylate and liquid or solid polymeric modifiers and adjuvant. The present adhesive formulations are useful as tissue adhesive/sealants, hemostatic agents, and as a means for patching or anastomic coupling of damaged organs.

Claims

1. A bioabsorbable adhesive formulation comprising an admixture of 2-alkoxyalkylcyanoacrylate and a trimethylene carbonate-based polymer.

2. The bioabsorbable adhesive formulation set forth in claim 1 wherein the trimethylene carbonate-based polymer comprises a homopolymer.

3. The bioabsorbable adhesive formulation set forth in claim 1 wherein the trimethylene carbonate-based polymer comprises a copolymer of trimethylene carbonate and one or more cyclic esters selected from the group consisting essentially of glycolide, lactide, p-dioxanone, ε

-caprolactone, and 1,5-dioxepan-2-one.

4. The bioabsorbable adhesive formulation set forth in claim 1 wherein the 2-alkoxyalkylcyanoacrylate comprises 2-methoxypropylcyanoacrylate.