Dermal penetration enhancers and drug delivery systems involving same

CAFC
  • US 6,299,900 B1
  • Filed: 12/18/1998
  • Issued: 10/09/2001
  • Est. Priority Date: 02/19/1996
  • Status: Expired due to Term
First Claim
Patent Images

1. A transdermal drug delivery system which comprises:

  • a therapeutically effective amount of at least one physiologically active agent; and

    at least one dermal penetration enhancer present in an amount of from 10 to 10,000 wt % based on the weight of the active agent;

    wherein the dermal penetration enhancer is at least one of a safe skin-tolerant ester sunscreen of formula (I);



    wherein R3 is hydrogen, lower alkyl, lower alkoxy, halide, hydroxy or NR3R4;

    R2 is a C8 to C18 alkyl, R3 and R4 are each independently hydrogen, lower alkyl or R3 and R4 together with the nitrogen atom to which they are attached form a 5- or 6-membered heterocyclic ring;

    n is 0 or 1, and q is 1 or 2, wherein when n is 0 and R1 is NR3R4, then NR3R4 is para-substituted.

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