Pharmaceutical composition

  • US 6,303,640 B1
  • Filed: 06/29/2000
  • Issued: 10/16/2001
  • Est. Priority Date: 06/20/1995
  • Status: Expired due to Term
First Claim
Patent Images

1. A method for reducing the side effects of respective active components administered to a diabetic patient, which comprises administering to said patient a therapeutically effective amount of a compound represented by the formula:

  • wherein R′

    represents an optionally substituted hydrocarbon or heterocyclic group;

    Y represents a group represented by —

    CO—

    , —

    CH(OH)—

    or —

    NR3

    wherein R3 represents an optionally substituted alkyl group;

    m is 0 or 1;

    n is 0, 1 or 2;

    X represents CH or N;

    A represents a bond or a C1-7 divalent aliphatic hydrocarbon group;

    Q represents an oxygen atom or sulfur atom;

    R1 represents hydrogen atom or an alkyl group;

    ring E may optionally have 1 to 4 further substituents, and the substituents may optionally be combined with R1 to form a ring;

    L and M respectively represent a hydrogen atom, or L and M may optionally be combined with each other to form a bond;

    with a proviso that R′

    does not represent benzopyranyl group when m and n are 0, X represents CH, A represents a bond, Q represents sulfur atom, R1, L and M represent hydrogen atoms and ring E does not have further substituents;

    or a pharmacologically acceptable salt thereof, in combination with an insulin secretion enhancer.

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