Chromium polynicotinate compositions and uses thereof for absorption of essential metals

• US 6,323,192 B1
• Filed: 08/08/2000
• Issued: 11/27/2001
• Est. Priority Date: 08/28/1998
• Status: Expired due to Term

• Current Assignee: Nutrition21 LLC
• Original Assignee: Ambi, Inc. (NXXI, Inc.)
• Inventors: Harpe, Jon de la, Price, Fredric D., Komorowski, James R., Skluth, Lauren K., Chakrin, Lawrence W.
• Primary Examiner(s): Henley, lll, Raymond
• Application Number:
  US09/634,664
• Time in Patent Office: 476 Days
• Field of Search: 424/725, 514/188, 514/356
• US Class Current: 514/188
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/09 having two or more such linkages
• CPC Class Codes: A61K 31/165 having aromatic rings, e.g. colchicine, atenolol, progabide
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/28 Compounds containing heavy metals
• CPC Class Codes: A61K 31/375 Ascorbic acid, i.e. vitamin C; Salts thereof
• CPC Class Codes: A61K 31/44 Non condensed pyridines; Hydrogenated derivatives thereof
• CPC Class Codes: A61K 31/455 Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
• CPC Class Codes: A61K 31/555 containing heavy metals, e.g. hemin, hematin, melarsoprol
• CPC Class Codes: A61K 31/60 Salicylic acid; Derivatives thereof
• CPC Class Codes: A61K 31/7004 Monosaccharides having only carbon, hydrogen and oxygen atoms
• CPC Class Codes: A61P 21/06 Anabolic agents androgens A61P5/26
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 3/08 for glucose homeostasis pancreatic hormones A61P5/48

Abstract

Compositions comprising chromic tripicolinate or chromic polynicotinate in the form of enteric-coated tablets, capsules or microbeads, optionally in combination with nicotinic acid, picolinic acid or both nicotinic acid and picolinic acid. The compositions are useful for supplementing dietary chromium, lowering blood glucose levels, lowering serum lipid levels and increasing lean body mass.

Claims

1. A method for facilitating absorption of essential metals to an individual, comprising orally administering to said individual a composition comprising chromium polynicotinate in combination with picolinic acid.

2. The method of claim 1, wherein said essential metals are selected from the group consisting of copper, iron, magnesium, manganese and zinc.

3. The method of claim 1, wherein the composition is incorporated into a pharmaceutically acceptable carrier.

4. The method of claim 3, wherein said carrier is selected form the group consisting of a tablet, capsule, microbead, emulsion, powder, granule, suspension, syrup and elixir.

5. The method of claim 4, wherein said microbead is a sugar beadlet or microcrystalline cellulose beadlet and said chromium polynicotinate and said picolinic acid are coated on said beadlet.

6. The method of claim 1, wherein said chromium polynicotinate and said picolinic acid are administered in a ratio of between about 1:

10 and about 10;

1 (w/w).

7. The method of claim 1, further comprising administering a cyclooxygenase inhibitor, an acid, a mucolytic, a salicin-containing herb, or combinations thereof.

8. The method of claim 1, further comprising administering nicotinic acid.

9. A method for facilitating absorption of essential metals to an individual, comprising orally administering to said individual a composition comprising chromium polynicotinate in combination with nicotinic acid.

10. The method of claim 9, wherein said essential metals are selected from the group consisting of copper, iron, magnesium, manganese and zinc.

11. The method of claim 9, wherein the composition is incorporated into a pharmaceutically acceptable carrier.

12. The method of claim 9, wherein said carrier is selected form the group consisting of a tablet, capsule, microbead, emulsion, powder, granule, suspension, syrup and elixir.

13. The method of claim 12, wherein said microbead is a sugar beadlet or microcrystalline cellulose beadlet and said chromium polynicotinate and said nicotinic acid are coated on said beadlet.

14. The method of claim 9, wherein said chromium polynicotinate and said nicotinic acid are administered in a ratio of between about 1:

10 and about 10;

1 (w/w).

15. The method of claim 9, further comprising administering a cyclooxygenase inhibitor, an acid, a mucolytic, a salicin-containing herb, or combinations thereof.