Gapped 2′ modified oligonucleotides

  • US 6,326,199 B1
  • Filed: 12/01/1999
  • Issued: 12/04/2001
  • Est. Priority Date: 12/24/1991
  • Status: Expired due to Fees
First Claim
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1. A method of concurrently enhancing hybridization and RNASE H activation in a cell comprising contacting the cell with an oligonucleotide having a sequence of nucleotides which specifically hybridize to a complementary strand of nucleic acid and where at least one of the nucleotides is functionalized to increase nuclease resistance of the oligonucleotide, where a plurality of the nucleotides have a substituent group located thereon to increase binding affinity of the oligonucleotide to a complementary strand of nucleic acid, and where a plurality of the nucleotides have 2′

  • -deoxy-erythro-pentofuranosyl sugar moieties.

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