Process for removing toxins from bodily fluids using zirconium or titanium microporous compositions

• US 6,332,985 B1
• Filed: 06/19/2000
• Issued: 12/25/2001
• Est. Priority Date: 03/29/1999
• Status: Expired due to Term

• Current Assignee: UOP Llc (Honeywell International Inc.)
• Original Assignee: UOP Llc (Honeywell International Inc.)
• Inventors: Sherman, John D., Lewis, Gregory J., Bem, David S.
• Primary Examiner(s): CINTINS, IVARS C
• Application Number:
  US09/597,337
• Time in Patent Office: 554 Days
• Field of Search: 210/638, 210/645, 210/646, 210/681, 210/687, 210/691, 210/903, 210/905, 210/908, 210/909
• US Class Current: 210/638
• CPC Class Codes: A61M 1/1678 intracorporal peritoneal dialysis A61M1/28
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: B01D 15/00 Separating processes involving the treatment of liquids with solid sorbents using liquid sorbents B01D11/00; ion exchange processes or materials, sorbent materials in general B01J, e.g. sorbents for chromatography B01J20/281; for investigating or analysing materials G01N30/00; Apparatus therefor
• CPC Class Codes: B01J 39/02 Processes using inorganic exchangers
• CPC Class Codes: Y10S 210/903 Nitrogenous

Abstract

A process for removing toxins from fluids, such as bodily fluids or a dialysate solution, is disclosed. The process involves contacting the fluid with a microporous ion exchanger to remove toxins in the fluid. The microporous ion exchangers are represented by the following empirical formulae:

A_pM_xZr_1−xSi_nGe_yO_m  (I)

and

A_pM_xTi_1−xSi_nGe_yO_m  (II)

Claims

1. A process for removing toxins from a fluid selected from the group consisting of a bodily fluid and a dialysate solution, the process comprising contacting the fluid containing the toxins with a microporous ion exchanger at ion exchange conditions thereby removing the toxins from the fluid, the microporous ion exchanger selected from the group consisting of zirconium metallate, titanium metallate and mixtures thereof, the metallates respectively having an empirical formula on an anhydrous basis of:

2. The process of claim 1 where the fluid is a bodily fluid selected from the group consisting of blood and gastrointestinal fluid.

3. The process of claim 2 where the microporous ion exchanger is orally ingested and contacted with gastrointestinal fluids of the body thereby removing toxins from said fluids.

4. The process of claim 1 where the fluid is a dialysate solution.

5. The process of claim 4 further comprising flowing the dialysate solution through a bed containing the microporous ion exchanger for a time sufficient to remove toxins from the dialysate solution.

6. The process of claim 1 where the toxin is ammonium ions.

7. The process of claim 1 where M is tin (+4).

8. The process of claim 1 where M is titanium (4+).

9. The process of claim 1 where M is niobium (5+).

10. The process of claim 1 where n=0.

11. The process of claim 1 where the A cation is exchanged for a different secondary cation, A′

, selected from the group consisting of alkali metals, alkaline earth metal, hydronium ions and mixtures thereof.

12. The process of claim 11 where A′

is a mixture of sodium and calcium ions.

13. The process of claim 11 where A′

is a mixture of sodium, calcium and hydronium ions.

14. A process for removing toxins from a mammalian body comprising:

a) filling the peritoneal cavity with a sufficient volume of a first dialysate solution such that the solution contacts the peritoneum for a sufficient time to remove toxins from the blood;

b) discharging the first dialysate solution from the peritoneal cavity and contacting the first dialysate solution with a microporous ion exchanger at ion exchange conditions, thereby adsorbing the toxins onto the ion exchanger; and

c) collecting a purified dialysate solution;

the microporous ion exchanger selected from the group consisting of zirconium metallate, titanium metallate and mixtures thereof, the metallates respectively having an empirical formula on an anhydrous basis of;

15. The process of claim 14 where the contacting of step (b) is carried out by flowing the dialysate solution through at least one bed containing a microporous ion exchanger.

16. The process of claim 14 where the contacting of step (b) is carried out by contacting the first dialysate solution with a semipermeable membrane such that the toxins flow through the membrane into a second dialysate solution and flowing the second dialysate solution through at least one bed containing a microporous ion exchanger.

17. The process of claim 14 where the purified dialysate solution is continuously recirculated to step (a) and steps (a) to (c) are carried out continuously.

18. The process of claim 14 where M is tin (+4).

19. The process of claim 14 where M is titanium (4+).

20. The process of claim 14 where M is niobium (5+).

21. The process of claim 14 where n=0.

22. The process of claim 14 where the A cation is exchanged for a different secondary cation, A′

, selected from the group consisting of alkali metals, alkaline earth metal, hydronium ions and mixtures thereof.

23. The process of claim 22 where A′

is a mixture of sodium and calcium ions.

24. The process of claim 22 where A′

is a mixture of sodium, calcium and hydronium ions.