Method of treating obstructive sleep apnea using implantable electrodes

• US 6,345,202 B2
• Filed: 03/20/2001
• Issued: 02/05/2002
• Est. Priority Date: 08/14/1998
• Status: Expired due to Term

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Advanced Bionics Corporation (Sonova Holding AG)
• Inventors: Loeb, Gerald E., Richmond, Frances J. R.
• Primary Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US09/812,447
• Publication Number:
  US 20010010010A1
• Time in Patent Office: 322 Days
• Field of Search: 607/42, 607/48, 607/72, 607/118, 607/2, 128/898
• US Class Current: 607/42
• CPC Class Codes: A61N 1/3601 of respiratory organs
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/3727 characterised by the modulation technique
• CPC Class Codes: A61N 1/37288 Communication to several implantable medical devices within one patient

Abstract

Electrodes are implanted at strategic locations within a patient and are then controlled in a manner so as to stimulate muscle and nerve tissue in a constructive manner which helps open blocked airways. In a preferred method, at least one microstimulator treats sleep apnea in an open loop fashion by providing electrical stimulation pulses in a rhythm or cycle having a period corresponding approximately to the natural respiratory rhythm of the patient. Such open loop stimulation entrains the patient'"'"'s respiratory rate to follow the pattern set by the microstimulator so that stimulation is applied to open the airway during a period of inspiration by the patient.

Claims

1. A method of treating obstructive sleep apnea (OSA) using an electrical stimulator controllable to provide electrical stimulation pulses in accordance with a regular stimulation pattern having a controlled rhythm comprising:

(a) determining an approximate natural respiration cycle of a patient;

(b) positioning electrodes in or on the patient at a location near the oropharynx muscles; and

(c) applying an electrical stimulus to the electrodes from the electrical stimulator at a rate that approximates the rate of a natural respiration cycle, wherein the oropharynx muscles are stimulated to pull open obstructed airways at a rhythm that is the same as or close to the natural respiration cycle;

wherein the respiratory rate of the patient is entrained to follow the rhythm of the electrical stimulator, whereby obstructed airways are kept open; and

wherein the electrodes comprise part of an injectable microstimulator.

2. The method of claim 1 wherein the positioning of the electrodes in or on the patient at a location near the oropharynx muscles comprises injecting the microstimulator so that the microstimulator is positioned near the oropharynx muscles.

3. The method of claim 2 wherein the step of applying an electrical stimulus to the electrodes comprises controlling the injectable microstimulators so that they provide a stimulus at a rate that approximates the natural respiration rate.

4. The method of claim 1 wherein determining the patient'"'"'s natural respiration rate comprises using a diagnostic face mask that simulates obstruction and opening of the patient'"'"'s airway at a controlled rate.

5. A method of treating obstructive sleep apnea (OSA) using an electrical stimulator controllable to provide electrical stimulation pulses in accordance with a regular stimulation pattern having a controlled rhythm comprising:

(a) determining an approximate natural respiration cycle of a subject;

(b) positioning electrodes near the oropharynx muscles of the subject; and

(c) applying an electrical stimulus to the electrodes to pull open obstructed airways at a rhythm that is the same as or close to the natural respiration cycle;

wherein the electrodes comprise part of an injectable microstimulator.

6. The method of claim 5 further comprising adjusting a rate of the applied stimulus so as to entrain the respiration cycle of the subject to follow the applied stimulus rate.

7. The method of claim 5 wherein positioning the electrodes near the oropharynx muscles comprises injecting the microstimulator so that the microstimulator is positioned near the oropharynx muscles.

8. The method of claim 6 wherein determining an approximate natural respiration cycle of the subject comprises using a diagnostic face mask that simulates obstruction and opening of the subject'"'"'s airway at a controlled rate.