Stent having cover with drug delivery capability

• US 6,379,382 B1
• Filed: 03/13/2000
• Issued: 04/30/2002
• Est. Priority Date: 03/13/2000
• Status: Expired due to Fees

• Current Assignee: Jun Yang
• Original Assignee: Jun Yang
• Inventors: Yang, Jun
• Primary Examiner(s): Willse, David H.
• Assistant Examiner(s): GHERBI, SUZETTE JAIME J
• Application Number:
  US09/524,650
• Time in Patent Office: 778 Days
• Field of Search: 623/1-9-
• US Class Current: 623/1.42
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2002/072 Encapsulated stents, e.g. wire or whole stent embedded in lining
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/12 Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00

Abstract

A prosthesis has a cylindrical stent, and a cover provided about the outer periphery of the stent. The cover has at least two layers of materials, with at least one layer of material being permeable to drugs. The layers of material can define at least one chamber therebetween, with a drug loaded into the at least one chamber. Alternatively, the drug can be loaded into the material of one or more layers.

Claims

1. A prosthesis, comprising:

a cylindrical stent having an outer periphery; and

a cover provided about the outer periphery of the stent, the cover comprising at least two layers of materials, with at least one layer of material being permeable to drugs;

wherein the two layers of material are stitched to the stent.

2. The prosthesis of claim 1, wherein the at least two layers of materials defines at least one chamber therebetween.

3. The prosthesis of claim 2, wherein a drug is loaded into the at least one chamber.

4. The prosthesis of claim 1, wherein one of the layers is made from a water absorbent material.

5. The prosthesis of claim 1, wherein one of the layers is made from a matrix of protein.

6. The prosthesis of claim 1, wherein the material of one of the layers is tissue.

7. The prosthesis of claim 1, wherein the material of one of the layers is hydrogel.

8. The prosthesis of claim 1, wherein the material of one of the layers is polymeric.

9. The prosthesis of claim 1, wherein one of the layers has at least one perforation.

10. The prosthesis of claim 1, wherein one of the layers is not impermeable to drugs.

11. The prosthesis of claim 1, wherein one of the at least two layers of materials is coated with another layer of material.

12. The prosthesis of claim 1, wherein one of the at least two layers of materials is loaded with a drug.

21. The prosthesis of claim 12, wherein the layers of material are stitched to the stent.

22. The prosthesis of claim 12, wherein one of the layers has at least one perforation.

23. The prosthesis of claim 12, wherein one of the layers is not impermeable to drugs.

24. The prosthesis of claim 12, wherein one of the layers of materials is coated with another layer of material.

13. A prosthesis, comprising:

a cylindrical stent having an outer periphery;

a cover provided about the outer periphery of the stent, the cover comprising at least two layers of materials, with at least one layer of material being permeable to drugs; and

wherein the at least two layers comprises three separate layers of material that define two separate chambers.

14. The prosthesis of claim 13, wherein the three separate layers includes a non-drug-permeable middle layer that separates the two chambers.

15. The prosthesis of claim 13, wherein a drug is loaded into at least one of the chambers.

16. The prosthesis of claim 13, wherein one of the layers is made from a water absorbent material.

17. The prosthesis of claim 13, wherein one of the layers is made from a matrix of protein.

18. The prosthesis of claim 13, wherein the material of one of the layers is tissue.

19. The prosthesis of claim 13, wherein the material of one of the layers is hydrogel.

20. The prosthesis of claim 13, wherein the material of one of the layers is polymeric.

25. The prosthesis of claim 13, wherein one of the layers of materials is loaded with a drug.

26. A cover for use in surrounding an outer periphery of a stent, comprising at least two layers of materials, with at least one layer of material being permeable to drugs;

and

wherein the at least two layers comprises three separate layers of material that define two separate chambers.

27. The cover of claim 26, wherein the at least two layers of materials defines at least one chamber therebetween.

28. The cover of claim 27, wherein a drug is loaded into the at least one chamber.

29. The cover of claim 26, wherein one of the layers is made from a water absorbent material.

30. The cover of claim 26, wherein one of the layers is made from a matrix of protein.

31. The cover of claim 26, wherein the material of one of the layers is tissue.

32. The cover of claim 26, wherein the material of one of the layers is hydrogel.

33. The cover of claim 26, wherein the material of one of the layers is polymeric.

34. The cover of claim 26, wherein one of the layers has at least one perforation.

35. The cover of claim 26, wherein one of the layers is not impermeable to drugs.

36. The cover of claim 26, wherein the three separate layers includes a non-drug-permeable middle layer that separates the two chambers.

37. The cover of claim 26, wherein one of the at least two layers of materials is coated with another layer of material.

38. The cover of claim 26, wherein one of the at least two layers of materials is loaded with a drug.

39. A method of delivering drugs to the lumen of a body vessel, comprising:

providing a prosthesis having a cylindrical stent having an outer periphery, and a cover provided about the outer periphery of the stent, the cover comprising at least two layers of materials, with at least one layer of material being permeable to drugs;

loading the cover with a releasable drug;

defining a first chamber in the cover and loading the drug in the first chamber;

defining a second chamber in the cover and loading a second drug into the second chamber;

delivering the prosthesis intraluminally to a desired location in a body vessel; and

releasing the drug from the cover.