Method and apparatus for using vagus nerve stimulation in surgery

• US 6,381,499 B1
• Filed: 05/17/2000
• Issued: 04/30/2002
• Est. Priority Date: 02/20/1996
• Status: Expired due to Fees

• Current Assignee: Maquet Cardiovascular LLC (Getinge AB)
• Original Assignee: Cardiothoracic Systems, Inc. (Boston Scientific Corporation)
• Inventors: Matheny, Robert G., Taylor, Charles S., Morejohn, Dwight P.
• Primary Examiner(s): LAYNO, CARL HERNANDZ
• Application Number:
  US09/574,586
• Time in Patent Office: 713 Days
• Field of Search: 607/118, 607/9, 607/63
• US Class Current: 607/118
• CPC Class Codes: A61B 17/122 Clamps or clips , e.g. for the umbilical cord for the vas deferens A61F6/206
• CPC Class Codes: A61B 17/1227 Spring clips
• CPC Class Codes: A61B 2017/0243 for immobilizing local areas of the heart, e.g. while it beats trocars attached to inner organs or inner body tissue A61B2017/3488

Abstract

A method and apparatus for facilitating coronary surgery on the beating heart wherein the vagus nerve is electrically stimulated to purposely temporarily stop or substantially reduce the beating of the heart under precisely controlled conditions. The apparatus controllably applies electrical stimulus to pre-selected locations along the vagus nerve and to pre-selected nerve branches related to the heart. The apparatus includes several clip and probe configurations for establishing electrical contact with the vagus nerve. Such purposely caused temporary stoppage or substantial reduction of the beating of the heart facilitates procedures such as suturing of an anastomosis which would otherwise be more difficult because of the motion induced by the beating heart.

Claims

1. A method of performing a selected surgical procedure on a patient'"'"'s beating heart, comprising the steps of:

momentarily arresting or substantially slowing the beating of the patient'"'"'s heart using electrical stimulation; and

performing at least one step of the selected surgical procedure while the patient'"'"'s heart is momentarily arrested or substantially slowed.

2. The method of claim 1, wherein said momentarily arresting or substantially slowing using electrical stimulation comprises applying an electrical stimulating signal to a selected position on a vagus nerve of the patient to stimulate the vagus nerve to momentarily arrest or substantially slow the beating of the patient'"'"'s heart.

3. The method of claim 1, further comprising the step of applying a heart pacing electrical signal to the patient'"'"'s heart to restore the beating of the heart after cessation of said momentarily arresting or slowing, in the event that the heart is slow to revive after said cessation.

4. The method of claim 2, wherein said applying an electrical stimulating signal lasts for a period of about 10 seconds or less.

5. The method of claim 2, wherein said electrical stimulating signal is intermittently applied for periods of about 10 seconds or less, with predetermined rest periods between intermittent applications.

6. The method of claim 5, wherein said predetermined rest periods last for about thirty seconds each.

7. The method of claim 1, wherein said performing at least one step of the selected surgical procedure while the patient'"'"'s heart is momentarily arrested or substantially slowed comprises performing at least one suturing step.

8. The method of claim 7, wherein the selected surgical procedure includes performing an anastomosis, and wherein said performing at least one suturing step comprises performing a series of suturing steps to complete the anastomosis, wherein at least one of said series of suturing steps is performed while the patient'"'"'s heart is momentarily arrested or substantially slowed.

9. The method of claim 8, wherein said momentarily arresting or substantially slowing comprises applying an electrical stimulating signal to a selected position on a vagus nerve of the patient to simulate the vagus nerve to momentarily arrest or substantially slow the beating of the patient'"'"'s heart.

10. The method of claim 9, wherein the vagus nerve is stimulated before each of the suturing steps in said series of suturing steps.

11. The method of claim 2, wherein said performing at least one step of the selected surgical precedure while the patient'"'"'s heart is momentarily arrested or substantially slowed comprises forming an arteriotomy in a coronary artery to be bypassed.

12. A system for performing a selected surgical procedure on a beating heart, said system comprising:

an electrical nerve stimulator for supplying a vagus nerve stimulating electrical signal from a location outside of a patient'"'"'s body; and

at least one electrical lead surrounded by insulative material with an electrode exposed from a distal end thereof, said electrode being adapted to be releasably fixed to the vagus nerve for supplying the vagus nerve stimulating electrical signal thereto.

13. The system of claim 12, wherein said electrode comprises an invasive needle or probe.

14. The system of claim 12, wherein said electrode comprises a non-invasive clip.

15. The system of claim 12, wherein said at least one said electrical lead with an electrode exposed comprises a plurality of said electrical leads, each of said electrodes adapted to contact the vagus nerve at different locations therealong.

16. The system of claim 15, wherein said plurality of electrical leads comprises a pair of electrical leads, each said electrical lead having one electrode exposed at an end thereof, wherein said electrodes are contacted with the vagus nerve in a bipolar arrangement.

17. The system of claim 16, wherein each said electrical lead comprises a clip with said electrode embedded therein.

18. The system of claim 12, wherein each of said at least one electrical leads comprises a clip having a pair of said electrode embedded therein, in opposition to one another.

19. The system of claim 18, wherein each said pair of electrodes has one electrode coupled to a positive potential of the electrical stimulator and the other electrode coupled to a negative potential.

20. The system of claim 12, further comprsing a heat pacing device connectable to the heart for reviving the heart, if needed, after cessation of the vagus nerve stimulating signal.