Topical drug preparations

• US 6,387,407 B1
• Filed: 03/30/1999
• Issued: 05/14/2002
• Est. Priority Date: 09/29/1995
• Status: Expired due to Term

• Current Assignee: Glycobiosciences Incorporated
• Original Assignee: L.A.M. Pharmaceutical, Corp.
• Inventors: Nath, Gary M., Drizen, Alan, Rothbart, Peter
• Primary Examiner(s): Dudash, Diana
• Assistant Examiner(s): Yu, Gina
• Application Number:
  US09/280,841
• Time in Patent Office: 1,141 Days
• Field of Search: 424/484, 424/485, 424/488, 514/54, 514/825, 514/886, 514/887, 514/944
• US Class Current: 424/488
• CPC Class Codes: A61K 31/196 the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 47/38 Cellulose; Derivatives thereof
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0034 Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
• CPC Class Codes: A61K 9/06 Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00

Abstract

Topical gelled compositions comprising an optional drug dispersed within a polymer matrix, methods of producing the same and treatments with the complex.

Claims

1. A process for the use of a composition as a medical device, for drug delivery, the application of a diagnostic agent, or the prevention of post operative adhesions, said process comprises topically administering to a mammal an aqueous based gelled composition containing a polymer matrix composed of a negatively charged polymer material blended with a nonionic polymer;

wherein the negatively charged polymer material is hyaluronate sodium salt; and

wherein the hyaluronate sodium salt has a weight average molecular weight from about 650,000 to about 800,000, a sulphated ash content below about 15%, a protein content below about 5% and purity of at least 98%.

2. The process of claim 1, wherein the negatively charged polymer material is selected from the group consisting of glucosminoglycans, mucopolysaccharides and mixtures thereof.

3. The process of claim 1, wherein the negatively charged polymer material has a weight average molecular weight below about 800,000.

4. The process of claim 1, wherein the negatively charged polymer material has a weight average molecular weight between 700,000 and 775,000.

5. The process of claim 1, wherein the nonionic polymer is selected from the group consisting of carboyxmethylcellulose sodium, hydroxyethyl cellulose, hydroxypropyl cellulose and mixtures thereof.

6. The process of claim 1, wherein the composition also contains an active therapeutic agent or drug.