Method for the prevention and treatment of cachexia and anorexia

• US 6,387,883 B1
• Filed: 08/18/2000
• Issued: 05/14/2002
• Est. Priority Date: 04/25/1996
• Status: Expired due to Term

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: DeMichele, Stephen Joseph, Cope, Frederick Oliver, Abbruzzese, Bonnie Chandler, McCamish, Mark Anthony
• Primary Examiner(s): Chang, Ceila
• Application Number:
  US09/642,630
• Time in Patent Office: 634 Days
• Field of Search: 424/523, 426/72, 426/601, 426/602, 426/656, 426/800, 426/801, 514/21, 514/578, 514/725, 514/730, 514/739
• US Class Current: 514/5.5
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23L 33/16 Inorganic salts, minerals or trace elements
• CPC Class Codes: A23L 33/175 Amino acids
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/02 Antioxidant
• CPC Class Codes: A23V 2200/30 Foods, ingredients or supplements having a functional effect on health
• CPC Class Codes: A23V 2200/308 having an effect on cancer prevention
• CPC Class Codes: A23V 2250/1626 Selenium
• CPC Class Codes: A23V 2250/1868 Docosahexaenoic acid
• CPC Class Codes: A23V 2250/187 Eicosapentaenoic acid
• CPC Class Codes: A23V 2250/211 Carotene, carotenoids
• CPC Class Codes: A23V 2250/5046 Fructan
• CPC Class Codes: A23V 2250/708 Vitamin C
• CPC Class Codes: A23V 2250/712 Vitamin E
• CPC Class Codes: A61K 31/202 having three or more double bonds, e.g. linolenic eicosanoids, e.g. leukotrienes A61K31/557
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 47/183 Amino acids, e.g. glycine, EDTA or aspartame
• CPC Class Codes: A61K 9/0029 Parenteral nutrition; Parenteral nutrition compositions as drug carriers
• CPC Class Codes: A61P 3/00 : Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/02 : Nutrients, e.g. vitamins, minerals
• CPC Class Codes: A61P 3/04 : Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: A61P 37/04 : Immunostimulants
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/00 : Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: Y10S 426/80 : Geriatric
• CPC Class Codes: Y10S 426/801 : Pediatric

Abstract

The present invention relates to methods and nutritional compositions for the prevention and treatment of cachexia and anorexia. The methods of the invention comprise administering a composition comprising effective amounts of ω-3 fatty acids such as alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid or mixtures thereof; of branched-chain amino acids valine, leucine, isoleucine or mixtures thereof; with or without reduced levels of tryptophan and 5-hydroxytryptophan; and of antioxidant system selected from the group comprising beta-carotene, vitamin C, vitamin E, selenium, or mixtures thereof.

Claims

1. A liquid nutritional composition comprising:

(a) at least 450 mg per liter of ω

-3 fatty acids, wherein the weight ratio of ω

-6 fatty acids to ω

-3 fatty acids is from about 0.1 to about 1.0, and;

(b) an antioxidant system comprising at least one ingredient selected from the group consisting of beta-carotene, vitamin C, vitamin E and selenium.

2. The composition according to claim 1 containing at least 1000 mg per liter of ω

-3 fatty acids.

3. The composition according to claim 1 in which said ω

-3 fatty acids are present in a quantity of about 1.0 gram to about 100 grams per liter.

4. The composition according to claim 1 in which said ω

-3 fatty acids are present in a quantity of about 1.0 grams to about 10 grams per liter.

5. The composition according to claim 1 further comprising at least 50 grams per liter of a source of amino nitrogen.

6. The composition according to claim 5, in which 15% to 50% by weight of the amino acids of said source of amino nitrogen are branched-chain amino acids which are present in a peptide, a protein, or as free amino acids.

7. The composition according to claim 6 in which said branched chain amino acids are selected from the group consisting of valine, leucine, and isoleucine.

8. The composition according to claim 1 in which said ω

-3 and said ω

-6 fatty acids are provided by a blend of oils, which includes fish oil in an amount ranging from 25% to 80% by weight of the oil blend.

9. A liquid nutritional composition comprising:

a) a source of amino nitrogen,

b) a source of carbohydrate,

c) a source of fats, in which said fats provide at least 450 mg per liter of ω

-3 fatty acids and a weight ratio of ω

-6 fatty acids to ω

-3 fatty acids of from about 0.1 to about 1.0, and;

d) an antioxidant system comprising at least one ingredient selected from the group consisting of beta-carotene, vitamin C, vitamin E and selenium.

10. The nutritional according to claim 9 containing at least 1000 mg per liter of ω

-3 fatty acids.

11. The nutritional according to claim 9 in which said ω

-3 fatty acids are present in a quantity of about 1.0 gram to about 100 grams per liter.

12. The nutritional according to claim 9 in which said ω

-3 fatty acids are present in a quantity of about 1.0 grams to about 10 grams per liter.

13. The nutritional according to claim 9 in which said source of amino nitrogen is provided by at least one constituent selected from the group consisting of protein, peptide, and amino acid and said constituent is present in a quantity of at least 50 grams per liter.

14. The nutritional according to claim 13, in which 15% to 50% by weight of said source of amino nitrogen is provided by branched chain amino acids which are present in a peptide, a protein or as free amino acids.

15. The nutritional according to claim 14 in which said branched chain amino acids are selected from the group consisting of valine, leucine, and isoleucine.

16. The nutritional according to claim 9 in which said fats are provided by a blend of oils, which includes fish oil in an amount ranging from 25% to 80% by weight of the oil blend.

17. The nutritional according to claim 9 in which said fats are provided by a blend of oils which includes medium chain triglyceride oil in an amount ranging from 10% to 50% by weight of the oil blend.

18. The nutritional according to claim 9 in which said source of amino nitrogen provides from about 12 to about 24% of total calories of said nutritional, said source of carbohydrate provides from about 40 to about 65% of total calories of said nutritional, and said fat provides from about 10 to about 35% of total calories of said nutritional.