Method of preparing and using isoflavones for the treatment of blood related illnesses

• US 6,391,308 B1
• Filed: 07/13/2000
• Issued: 05/21/2002
• Est. Priority Date: 03/13/1996
• Status: Expired due to Fees

• Current Assignee: Archer Daniels Midland Company
• Original Assignee: Archer Daniels Midland Company
• Inventors: Empie, Mark, Gugger, Eric
• Primary Examiner(s): Gitomer, Ralph
• Assistant Examiner(s): Khare, Devesh
• Application Number:
  US09/615,239
• Time in Patent Office: 677 Days
• Field of Search: 424/195.1, 514/783, 514/26, 514/25, 514/27, 514/568, 514/717, 514/720, 514/824
• US Class Current: 424/757
• CPC Class Codes: A23L 33/105 Plant extracts, their artificial duplicates or their derivatives
• CPC Class Codes: A23L 33/11 Plant sterols or derivatives thereof, e.g. phytosterols
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2250/2116 Flavonoids, isoflavones
• CPC Class Codes: A23V 2250/2132 Other phenolic compounds, polyphenols
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 36/48 Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
• CPC Class Codes: A61K 36/488 Pueraria (kudzu)
• CPC Class Codes: A61K 36/55 Linaceae (Flax family), e.g. Linum
• CPC Class Codes: A61K 36/68 Plantaginaceae (Plantain Family)
• CPC Class Codes: A61K 36/82 Theaceae (Tea family), e.g. camellia
• CPC Class Codes: A61K 36/899 Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 15/02 for disorders of the vagina
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 25/20 Hypnotics; Sedatives
• CPC Class Codes: C07D 311/36 not hydrogenated in the hetero ring, e.g. isoflavones

Abstract

A composition is prepared by extracting phytochemicals from plant matter and is administered to provide treatment for cardiovascular medical conditions, such as: excessive bloodstream cholesterol, the risk of heart disease, abnormal blood lipid profiles, and abnormal vascular effects. This composition is enriched preferably with two or more fractions of plant matter, namely: isoflavones, lignans, saponins, sapogenins, catechins and phenolic acids. The isoflavones are selected from a group including malonyl, acetyl, glucoside and aglycone. Soy is the preferred source of these chemicals; however, other plants may also be used, such as wheat, psyllium, rice, oats, red clover, kudzu, alfalfa, flax, and cocoa. The composition is a dietary supplement in a concentrated form, preferably in an easy to consume form, for treatment of various cardiovascular conditions and various other related disorders.

Claims

1. A composition for treatment of cardiovascular conditions, said composition being made from a plant matter in which the composition is a medicament enriched in at least two of the phytochemicals selected from the group consisting of isoflavones, lignans, saponins, sapogenins, catechins and phenolic acids, said medicament having a therapeutic treatment amount of phytochemicals selected on a basis of a therapeutic treatment for a cardiovascular condition.

2. The composition of claim 1 in which the ratio of isoflavones to saponins is selected from the range of about 1:

10 to about 10;

1.

3. The composition of claim 1 in which the isoflavones are present in an amount from approximately 5% to approximately 90% by weight.

4. The composition of claim 1 in which said medicament is in a form of a product for oral delivery, said product form being selected from a group consisting of a concentrate, liquid, soft gel, dried powder, capsule, pellet, pill, suspensions, emulsions, and a food supplement including health bars.

5. The composition of claim 4 wherein the product comprises between about 15% and about 25% by weight of the medicament and between about 65% and about 85% by weight of a filler.

6. The composition of claim 4 wherein the product comprises:

a. between about 15% and about 25% by weight of the medicament;

b. between about 60% and about 84% by weight of a filler; and

c. between about 1% and about 25% by weight of a dietary supplemental nutrient.

7. The composition of claim 1 in which the lignans are present in an amount from about 1% to about 70% by weight.

8. The composition of claim 1 wherein said therapeutic amount of said medicament is selected on a basis of a treatment for a coronary heart disease.

9. The composition of claim 1 wherein said therapeutic amount of said medicament is selected on a basis of a treatment for modulating a cardiovascular development.

10. The composition of claim 1 wherein said therapeutic amount of said medicament is selected on a basis of a treatment for modulating blood lipid profiles.

11. The composition of claim 1 wherein said therapeutic amount of said medicament is selected on a basis of a treatment of vascular conditions.

12. The composition of claim 1 wherein said isoflavones are selected from a group consisting of malonyl, acetyl, glucoside, and aglycone.

13. The composition of claim 1 wherein said composition is a food in a form of a concentrated, easy to consume dosage.

14. A method of treating a human subject for a cardiovascular condition, said method comprising the step of administering to the human subject a therapeutically effective amount of a composition for treating said condition, said composition being extracted from plant matter which is enriched in at least two phytochemical fractions.

15. The method of claim 14 wherein said phytochemical fractions are selected from the group of isoflavones, lignans, saponins, sapogenins, catechins, and phenolic acids.

16. The method of claim 15 wherein said isoflavones are selected from a group consisting of malonyl, acetyl, glucoside, and aglycone and said composition is in a form selected from a group consisting of a concentrate, liquid, soft gel, dried powder, capsule, pill, suspension, emulsions, and food supplements including health bars.