Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
First Claim
1. A hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment, said copolymer comprising:
- a hydrophobic polyester block X and a hydrophilic block Y, said blocks X and Y being covalently bonded together in an arrangement selected from the group consisting of X-Y-X, (X-Y)n, and branched structures thereof;
said hydrophobic block comprising greater than 50% of the mass of said copolymer and derived front a process selected from the group consisting of ring-opening of a cyclic carbonate and step-growth polymerization of an alkylene carbonate.
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Abstract
The present invention provides novel hydrogel-forming, self-solvating, absorbable polyester copolymers capable of selective, segmental association into compliant hydrogels upon contacting an aqueous environment. Methods of using the novel polyester copolymers of the invention in humans are also disclosed for providing a protective barrier to prevent post-surgical adhesion, treatment of defects in conduits such as blood vessels, and controlled release of a biologically active agent for modulating cellular events such as wound healing and tissue regeneration or therapeutic treatment of diseases such as infection of the periodontium, dry socket, bone, skin, vaginal, and nail infections.
278 Citations
55 Claims
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1. A hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment, said copolymer comprising:
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a hydrophobic polyester block X and a hydrophilic block Y, said blocks X and Y being covalently bonded together in an arrangement selected from the group consisting of X-Y-X, (X-Y)n, and branched structures thereof;
said hydrophobic block comprising greater than 50% of the mass of said copolymer and derived front a process selected from the group consisting of ring-opening of a cyclic carbonate and step-growth polymerization of an alkylene carbonate. - View Dependent Claims (2, 3, 4, 21, 24, 25, 26, 27, 28, 32, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 50)
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5. A composition comprising:
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a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment;
a low molecular weight component associated with said copolymer; and
an absorbable microparticulate solid carrier associated with said copolymer and said component, said carrier having a biological active agent or mixtures of biologically active agents deposited thereon. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 22, 23, 29, 30, 31, 33, 34, 35, 36, 51)
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14. A composition comprising:
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a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment; and
an absorbable microparticulate, microporus, carrier associated with said copolymer, said carrier having a biological active agent deposited thereon; and
the surface of said carrier being anionic and complexing with said agent. - View Dependent Claims (15)
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16. A composition comprising:
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a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment; and
an absorbable microparticulate, microporus, carrier associated with said copolymer, said carrier having a biological active agent deposited thereon; and
the surface of said carrier being cationic and complexing with said agent. - View Dependent Claims (17)
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- 18. A method of treating ocular diseases or disorders in a patient suffering from such diseases comprising, placing at the site of said disease a formulation comprising a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment and a pharmaceutically acceptable carrier.
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20. A method of accelerating incisional wound healing and reducing scaring in a patient comprising placing at the site of said disease a formulation consisting of a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment and a pharmaceutically acceptable carrier.
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49. A method for treating osteomyelitis in a person suffering from such a condition comprising placing at the site of the condition the formulation according to Examples XX and XXVII.
- 52. A process for making an encased microparticle comprising the step of encasing a bound microparticle with an absorbable polymer.
Specification