Plate locator for precision liquid handler

• US 6,416,719 B1
• Filed: 01/19/2001
• Issued: 07/09/2002
• Est. Priority Date: 01/19/2001
• Status: Expired due to Term

• Current Assignee: Gilson, Inc.
• Original Assignee: Gilson, Inc.
• Inventors: Fawcett, Kevin R., Acker, Jeffrey L.
• Primary Examiner(s): Warden, Jill
• Assistant Examiner(s): Gordon, Brian R.
• Application Number:
  US09/766,136
• Publication Number:
  US 20020098115A1
• Time in Patent Office: 536 Days
• Field of Search: 422/63, 422/68.1, 422/67, 422/100, 422/102, 422/104, 422/99, 248/678, 248/346.03, 248/346.04
• US Class Current: 422/561
• CPC Class Codes: B01J 2219/00317 Microwell devices, i.e. having large numbers of wells
• CPC Class Codes: B01J 2219/00351 Means for dispensing and evacuation of reagents
• CPC Class Codes: B01J 2219/00691 using robots
• CPC Class Codes: B01L 2300/0829 Multi-well plates; Microtitration plates
• CPC Class Codes: B01L 9/523 for multisample carriers, e.g. used for microtitration plates
• CPC Class Codes: C40B 60/14 for creating libraries
• CPC Class Codes: G01N 2035/0425 Stacks, magazines or elevators for plates
• CPC Class Codes: G01N 2035/0427 nestable or stockable
• CPC Class Codes: G01N 35/0099 comprising robots or similar manipulators robots per se B25J
• CPC Class Codes: G01N 35/04 Details of the conveyor system G01N35/021 - G01N35/028 take precedence
• CPC Class Codes: G01N 35/1065 Multiple transfer devices

Abstract

A locator bed has nests where sample well containing plates are held and positioned for accessing by probes moved by an X-Y-Z positioning system. Each nest includes stop posts at two sides of a rectangular base of a plate, and biasing posts at the opposed two sides. The stop posts and the biasing posts have tapered upper guide portions for guiding a descending plate into position and cylindrical lower portions receiving the base of the plate in a seated position. The stop posts are located on the surface of the locator bed by conical seat portions. The biasing posts are placed over studs fastened to the bed surface, and hoop springs are captured between the studs and the biasing posts.

Claims

1. A plate locator for positioning and holding a four sided plate having an array of sample containing wells, such as a microplate, on a work bed of a precision liquid handler having at least one probe for registration with at least one well of the plate, said plate locator apparatus comprising:

a flat, planar locator bed adapted to be secured to the work bed of the precision liquid handler;

a plate receiving nest on said locator bed, said nest having four sides corresponding to the four sides of the four sided plate;

said nest including rigid stop members extending up from said bed on first and second sides of said nest;

said nest including movably mounted holders extending up from said bed at third and fourth sides of said nest opposite said rigid stop members at said first and second sides of said nest; and

resilient biasing elements connected between said bed and each of said movably mounted holders for urging said holders toward the center of said nest.

2. The plate locator of claim 1, wherein there are only three said rigid stop members and only two said movably mounted holders.

3. The plate locator of claim 2, said two movably mounted holders being located near a first corner where said third and fourth sides intersect, and two of said three rigid stop member being located near a second corner opposite said first corner.

4. The plate locator of claim 1, further comprising access recesses in said bed adjacent an opposed pair of sides of said nest.

5. The plate locator of claim 1, said rigid stop members comprising stop posts.

6. The plate locator of claim 5, said bed having a conical recess for each of said stop posts, said stop posts being circular in cross section throughout their lengths and each having a conical bottom portion received in a corresponding said conical recess.

7. The plate locator of claim 1, each of said movably mounted holders comprising a biasing post.

8. The plate locator of claim 7, further comprising a stud secured to said bed for each said biasing post, said biasing post having a central cavity receiving said stud.

9. The plate locator of claim 8, said resilient biasing element comprising a spring in said cavity between said stud and said biasing post.

10. The plate locator of claim 9, said stud and said biasing post having circular cross sections and defining an annular spring receiving chamber between said stud and biasing post in said cavity, said spring being received in said annular chamber.

11. The plate locator of claim 10, said spring comprising a hoop spring having coils surrounding a circular axis.

12. The plate locator of claim 1, said rigid stop members and said movably mounted holders comprising posts having vertical portions immediately adjacent said bed and having inclined plate guide portions above said vertical portions.