Infrared ATR glucose measurement system having an ATR with mirrored ends

• US 6,421,548 B1
• Filed: 09/22/2000
• Issued: 07/16/2002
• Est. Priority Date: 10/13/1998
• Status: Expired due to Fees

• Current Assignee: Vivomedical, Inc. (Biotech-IgG Equity AB)
• Original Assignee: Medoptix Incorporated
• Inventors: Roe, Jeffrey N., Berman, Herbert L.
• Primary Examiner(s): Winakur, Eric F.
• Assistant Examiner(s): KREMER, MATTHEW J
• Application Number:
  US09/668,207
• Time in Patent Office: 662 Days
• Field of Search: 600/309-310, 600/322-324, 600/316, 600/365, 356/39-42
• US Class Current: 600/322
• CPC Class Codes: A61B 2562/245 Means for cleaning the sensor in-situ or during use, e.g. hygienic wipes
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: G01N 21/552 Attenuated total reflection

Abstract

This involves a non-invasive glucose measurement device and a process for determining blood glucose level in the human body using the device. In typical operation, the glucose measurement device is self-normalizing in that it does not employ an independent reference sample in its operation. The device uses attenuated total reflection (ATR) infrared spectroscopy. Preferably, the device is used on a fingertip and compares two specific regions of a measured infrared spectrum to determine the blood glucose level of the user. Clearly, this device is especially suitable for monitoring glucose levels in the human body, and is especially beneficial to users having diabetes mellitus. The device and procedure may be used for other analyte materials which exhibit unique mid-IR signatures of the type described herein and that are found in appropriate regions of the outer skin.

Claims

1. An analyte level measurement device for measuring said analyte level in a human body by contacting a skin surface, comprising:

a.) an infared source for emitting an IR beam into an ATR plate through a single incident surface, said IR beam having components at least in the region of a referencing wavelength and a measuring wavelength,

b.) said ATR plate having a measurement surface for contact with said skin surface and for directing said IR beam against said skin surface, said ATR plate being configured to further direct said IR beam to exit said ATR plate through said incident surface,

c.) at least two IR sensors for simultaneously measuring absorbance of at least said referencing wavelength and said measuring wavelength, and

d.) a calculator for determining said analyte level using said measured absorbance of said skin surface.

2. The analyte level measurement device of claim 1, wherein said ATR plate comprises a mirrored end to direct said IR beam to exit said ATR plate.

3. The analyte level measurement device of claim 2, wherein said mirrored end is substantially hemispherical.

4. The analyte level measurement device of claim 1, wherein said infrared source and said at least two IR sensors are all disposed near said incident surface of said ATR plate.

5. The analyte level measurement device of claim 2, wherein said ATR plate is configured to have said IR beam reflected internally at least once by said measurement surface, said ATR plate being further configured to have said IR beam reflected by said mirrored end to redirect said IR beam at least twice through said ATR plate.