Adaptive calibration pulsed oximetry method and device

• US 6,421,549 B1
• Filed: 07/14/2000
• Issued: 07/16/2002
• Est. Priority Date: 07/14/1999
• Status: Expired due to Term

• Current Assignee: Providence Health System - Oregon
• Original Assignee: Providence Health System - Oregon
• Inventors: Jacques, Steven L.
• Primary Examiner(s): Winakur, Eric F.
• Assistant Examiner(s): KREMER, MATTHEW J
• Application Number:
  US09/616,465
• Time in Patent Office: 732 Days
• Field of Search: 600/309-310, 600/322-324, 600/330-331, 356/39-42
• US Class Current: 600/331
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: G01N 21/274 Calibration, base line adjustment, drift correction
• CPC Class Codes: G01N 21/3151 using two sources of radiation of different wavelengths G01N21/33 - G01N21/39 take precedence

Abstract

A method for determining an arterial blood oxygen saturation level according to this invention includes measuring the light transmittance through tissue of light of a first wavelength and a second wavelength. A steady-state component of the measured light transmission is used to select an appropriate calibration curve. A pulsatile component of the measured light transmission is used to determine the arterial blood oxygen saturation level using the selected calibration curve. An oximetry system is also provided.

Claims

1. A method for calibrating an oximeter for use in determining an arterial blood oxygen saturation level in tissue, comprising:

determining a steady-state component of a light transmission through or reflection from a tissue at each of a first and second wavelengths;

using the steady-state component of the light transmission or reflection to select a calibration curve, said calibration curve representing a level of arterial blood oxygen saturation in relation to a pulsatile factor;

determining the pulsatile factor; and

determining the arterial blood oxygen saturation level using the selected calibration curve and the pulsatile factor.

2. A method according to claim 1, wherein the calibration curve is chosen from a set of calibration curves, and wherein the set of calibration curves is selected from a plurality of sets of calibration curves.

3. A method according to claim 1, wherein the steady-state component of the light transmissions of the first and second wavelengths are determined by comparing measured amounts of light of the first and second wavelengths passing through a standard medium with measured amounts of light of the first and second wavelengths, respectively, passing through the tissue.

4. A method according to claim 3, wherein the comparison generates ratios of the measured amount of light in tissue to the measured amount of light in the standard medium for each wavelength, and wherein the ratios are uniquely mapped to a blood volume fraction and a mixed blood oxygen saturation value.

5. A method according to claim 1, wherein determining the pulsatile factor is performed by measuring and comparing the AC and time averaged DC components of the light transmission through or reflected from the tissue.

6. A method according to claim 1, wherein the steady-state component of the light transmissions or reflections of the first and second wavelengths are uniquely mapped to a blood volume fraction and a mixed blood oxygen saturation value.

7. A method according to claim 1, further comprising normalizing the steady-state component of the light transmission or reflection to remove the effects of variation of a strength of a light source and a sensitivity of a transducer from the steady-state component.

8. A method according to claim 1, wherein the calibration curve is chosen using a mixed blood oxygen saturation value and a blood volume fraction.

9. A method according to claim 1, further comprising repeatedly measuring an amount of light of the first and the second wavelengths passing through or reflected from the tissue, and repeatedly reselecting an appropriate calibration curve based on the steady-state component of the measured amounts of light passing through the tissue or reflected from the tissue to adaptively calibrate in response to changes in a mixed oxygen saturation level and a blood volume fraction level.

20. A computer readable medium containing instructions adapted to cause a computer to perform the method of claim 1.

10. An oximetry system for measuring arterial blood oxygen saturation levels in a tissue, comprising:

a light source configured to transmit light of a first wavelength and a second wavelength to a medium;

a light transducer configured to measure an amount of the light of each of the first and second wavelengths transmitted through or reflected from the medium and to generate light measurement data corresponding to the measured amount of light; and

a data processor configured to use one or more steady-state components of the light measurement data to adaptively select a calibration curve, said calibration curve being representative of an amount of arterial blood oxygen saturation relative to a pulsatile factor.

11. An oximetry system according to claim 10, wherein the data processor is further configured to repeatedly reselect a calibration curve based on changes in a blood volume fraction level and a mixed blood oxygen saturation level.

12. An oximetry system according to claim 10, wherein the data processor is configured to determine the pulsatile factor based on a ratio of pulsatile components of the light measurements normalized by the steady-state components of the light measurement data, and is further configured to determine an arterial blood oxygen saturation value using the pulsatile factor and the selected calibration curve.

13. An oximetry system according to claim 10, wherein the data processor is configured to normalize the light measurement data by calculating a ratio of the light measurement in the tissue to a light measurement in a standard medium.

14. An oximetry system according to claim 10, wherein the data processor is further configured to normalize the light measurement data into normalized light measurements and to select a calibration curve using a grid mapping, wherein the grid mapping uniquely maps the normalized light measurements into a blood volume fraction and a mixed blood oxygen saturation value, and wherein the blood volume fraction and mixed blood oxygen saturation value can be used to select the calibration curve.

15. A method of measuring an arterial blood oxygen saturation level in a tissue, comprising:

comparing steady-state light measurements in a standard medium of light of a first and second wavelengths with steady-state light measurements in the tissue of the light of the first and second wavelengths;

measuring an amount of the light of the first and second wavelengths transmitted through or reflected from the tissue to obtain a light measurement for each wavelength;

using steady-state components of the light measurements to select a calibration curve; and

using the selected calibration curve to determine an arterial blood oxygen saturation level in the tissue.

16. A method according to claim 15, wherein comparing light measurements comprises normalizing the light measurements in the tissue by calculating a ratio between the light transmission measurement in the tissue and a light transmission measurement in a calibration material for light of each of the first and second wavelengths.

17. A method according to claim 16, further comprising using a grid mapping to translate the normalized light measurement into a blood volume fraction and a mixed blood oxygen saturation value, wherein optical transport theory is used to create a unique mapping between the normalized light measurements and the blood volume fraction and the mixed blood oxygen saturation value.

18. A method according to claim 15, wherein using the steady-state component of the light measurements to select an appropriate calibration curve comprises:

using the steady-state component of the light measurements to determine a blood volume fraction and a mixed blood oxygen saturation value;

using the mixed blood oxygen saturation value and the blood volume fraction to select the calibration curve from a plurality of sets of calibration curves.

19. A method according to claim 15, further comprising:

calculating a pulsatile factor using pulsatile signals normalized by the steady-state component of the light measurements at the first and second wavelengths; and

using the pulsatile factor and the selected calibration curve to determine the arterial blood oxygen saturation level.

21. A method of generating a function grid relating optical properties of a tissue to a blood volume fraction and a mixed blood oxygen saturation level, comprising:

generating a light transport function for light of a first wavelength as a function of absorption and scattering coefficients and a geometry of a probe;

generating a light transport function for light of a second wavelength as a function of absorption and scattering coefficients and the geometry of the probe; and

using the light transport functions for light of the first and second wavelengths in conjunction with spectral optical absorption properties of blood and tissue components to generate a function grid relating measured light transmission or reflectance of a tissue to a blood volume fraction and a mixed blood oxygen saturation level.