Synchronizing of animal oestrus and intra vaginal devices useful therein
First Claim
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1. An intra vaginal device for insertion into a vaginal cavity of an animal selected from the group consisting of cattle, sheep, deer and goats, retainable therein over a period of time within a range of from 7 to 12 days and then to be withdrawable therefrom to allow the onset of oestrus, said device comprising:
- a matrix of a cured silicone rubber material including greater than 5% by weight progesterone to a weight of the matrix and defining an exterior surface of at least 75 cm2 contactable upon insertion in the vagina of an animal by biological fluids of the animal, a total progesterone load being from 1 to 1.5 grams within said matrix, said exterior surface being at least substantially all available for progesterone release and said exterior surface having said progesterone load having a thickness of less than 1 millimeter, and said matrix, upon vaginal insertion in an animal, achieving and then maintaining, for at least seven days, a minimum progesterone blood plasma level of 2 nanograms per milliliter of plasma of the animal and after seven days from insertion having a residual load in the matrix of less than 65% by weight of the total progesterone load at insertion.
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Abstract
An intra vaginal device which is of a variable geometry and which includes a silicone matrix impregnated with progesterone, the confirmation and content of the progesterone impregnated matrix being such as to optimize effectiveness with a lower initial loading of progesterone.
88 Citations
11 Claims
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1. An intra vaginal device for insertion into a vaginal cavity of an animal selected from the group consisting of cattle, sheep, deer and goats, retainable therein over a period of time within a range of from 7 to 12 days and then to be withdrawable therefrom to allow the onset of oestrus, said device comprising:
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a matrix of a cured silicone rubber material including greater than 5% by weight progesterone to a weight of the matrix and defining an exterior surface of at least 75 cm2 contactable upon insertion in the vagina of an animal by biological fluids of the animal, a total progesterone load being from 1 to 1.5 grams within said matrix, said exterior surface being at least substantially all available for progesterone release and said exterior surface having said progesterone load having a thickness of less than 1 millimeter, and said matrix, upon vaginal insertion in an animal, achieving and then maintaining, for at least seven days, a minimum progesterone blood plasma level of 2 nanograms per milliliter of plasma of the animal and after seven days from insertion having a residual load in the matrix of less than 65% by weight of the total progesterone load at insertion. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. An intra vaginal device for insertion into a vaginal cavity of an animal selected from the group consisting of cattle, sheep, deer and goats, retainable therein over a period of time within a range of from 7 to 12 days and then to be withdrawable therefrom to allow the onset of oestrus, said device comprising:
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a frame having a matrix of a cured silicone rubber material including greater than 5% and less than 20% by weight progesterone to a weight of the matrix, the matrix defining an exterior surface of at least 100 cm2 contactable upon insertion in the vagina of an animal by biological fluids of the animal, a total progesterone load being from 1 to 1.5 grams within said matrix, said exterior surface being at least substantially all available for progesterone release and said exterior surface having said progesterone load having a thickness of less than 1 millimeter, and said matrix, upon vaginal insertion into an animal, achieving and then maintaining, for at least seven days, a minimum progesterone blood plasma level of 2 nanograms per milliliter of plasma of the animal and after seven days from insertion having a residual load in the matrix of less than 60% by weight of the total progesterone load at insertion.
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9. An intra vaginal device for insertion in a vaginal cavity of an animal selected from the group consisting of cattle, sheep, deer and goats, and retainable therein over a period of time and then to be withdrawable therefrom to allow the onset of oestrus, said device comprising:
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a matrix of cured silicone rubber material including greater than 5% by weight of progesterone to a weight of the matrix, said matrix having at least one progesterone release surface, said at least one release surface having a total area of at least 75 cm2 contactable, once inserted in the vagina of an animal, by the biological fluids of the animal, substantially all of the progesterone within the matrix being within about 1 millimeter of said at least one release surface, a total progesterone load being at least 1 gram within said matrix, said matrix, upon vaginal insertion into an animal, achieving and then maintaining in the animal, for at least seven days, a minimum progesterone blood plasma level of 2 nanograms per milliliter of plasma of the animal and if removed after seven days from insertion having a residual progesterone load in the silicone rubber matrix of less than 1 gram and also less than 65% by weight of the total progesterone load at insertion. - View Dependent Claims (10)
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11. An intra vaginal device for insertion into a vaginal cavity of an animal selected from the group consisting of cattle, sheep, deer and goats, and retainable therein over a period of time and then to be withdrawable therefrom to allow the onset of oestrus, said device comprising
a matrix of cured silicone rubber material including greater than 5% by weight of progesterone to a weight of the matrix, said matrix having at least one progesterone release surface, said at least one release surface having a total area of at least 75 cm2 contactable, once inserted in the vagina of an animal, by the biological fluid of the animal, the progesterone, the cured silicone rubber material and said at least one progesterone release surface producing a zero-order intra vaginal release rate of progesterone from the matrix, substantially all of the progesterone within the matrix being less than 1 millimeter from said at least one progesterone release surface, a total progesterone load being at least 1 gram within said matrix, and said matrix, upon vaginal insertion into an animal, achieving and then maintaining in the animal, for at least seven days, a minimum progesterone blood plasma level of 2 nanograms per milliliter of plasma of the animal and if removed after seven days from insertion having a residual load or progesterone in the silicone rubber matrix of less than 1 gram and also less than 65% by weight of the progesterone load at insertion.
Specification