Waveform interpreter for respiratory analysis

• US 6,428,483 B1
• Filed: 06/08/2000
• Issued: 08/06/2002
• Est. Priority Date: 06/08/1999
• Status: Expired due to Term

• Current Assignee: Oridion Medical 1987 Limited (Medtronic Plc)
• Original Assignee: Oridion Medical 1987 Limited (Medtronic Plc)
• Inventors: Carlebach, Ephraim
• Primary Examiner(s): Nasser, Robert L.
• Assistant Examiner(s): MALLARI, PATRICIA C
• Application Number:
  US09/590,202
• Time in Patent Office: 789 Days
• Field of Search: 600/532, 600/529
• US Class Current: 600/532
• CPC Class Codes: A61B 5/0836 Measuring rate of CO2 production

Abstract

A capnograph which performs an analysis of the breath waveforms measured by the carbon dioxide sensor, interprets the results of this analysis, and outputs to the operator diagnostic information about the respiratory status of the patient, or about the adequacy of the breathing support provided to the patient. The instrument compares a number of parameters characteristic of the waveforms of the patient'"'"'s breath with an internal library of the values of those parameters expected from normal waveforms stored in its memory. These parameters may either relate to specific features of the waveform in the time domain, or may characterize spectral components of the waveform in the frequency domain. The capnographic waveform analysis may be combined with further non-invasive measurements in order to provide an indication of the deviation of the value of EtCO₂ from PaCO₂.

Claims

1. Apparatus for computerized breath analysis comprising:

a breath receiver in fluid communication with a subject;

a breathing analyzer coupled to the breath receiver and operative to analyze a plurality of sequential breath waveforms of said subject and provide at least one output; and

a respiration diagnosis generator utilizing said at least one output of said breathing analyzer to provide an indication of the respiratory status of the subject based on a relationship between multiple ones of said plurality of breath waveforms.

2. Apparatus according to claim 1 and wherein said breathing analyzer includes a capnograph.

3. Apparatus according to claim 1 and wherein said breathing analyzer compares a plurality of said sequential breath waveforms with at least one reference.

4. Apparatus according to claim 1 and wherein said breathing analyzer analyzes variations in said plurality of breath waveforms over time for detecting changes in said respiratory status of said subject.

5. Apparatus according to claim 4 and also comprising a trend analyzing unit for comparing said variations over time in said plurality of waveforms with predefined variations over time in time-sequenced waveforms typical of patients with known respiratory deficiencies.

6. Apparatus for providing an indication of the clinical respiratory state of a subject, comprising:

a gas analyzer which provides a plurality of sequential waveforms of the partial pressure of the breath of a subject;

a signal processor for analyzing said plurality of sequential waveforms for at least one parameter which characterizes a property of said waveforms;

a parameter comparator for comparing values of said at least one parameter with a predefined parameter which characterizes the same property of a waveform obtained from a normal subject; and

a diagnosis generator which generates a response in accordance with the changes in the output of said parameter comparator.

7. Apparatus according to claim 6 and wherein said gas analyzer is a capnograph.

8. Apparatus for providing an indication of the respiratory state of a subject, comprising:

a gas analyzer which provides a plurality of time-sequenced waveforms of the breath of a subject;

an input circuit for receiving a sequence of digitized signals derived from said plurality of time-sequenced waveforms;

a signal processor for analyzing said sequence of digitized signals for determining changes with time in at least one parameter of said plurality of time-sequenced waveforms;

a trend analyzing unit for comparing said changes with time in said at least one parameter of said plurality of time-sequenced waveforms, with predefined changes with time in the equivalent said at least one parameter of time-sequenced waveforms typical of patients with known respiratory deficiencies; and

a diagnosis generator which generates a message in accordance with the output of said trend analyzing unit.

9. Apparatus according to claim 8 and wherein said gas analyzer is a capnograph.

10. Apparatus for computerized breath analysis comprising:

a breath receiver in fluid communication with a subject;

a breathing analyzer coupled to the breath receiver and comprising a waveform parameter extractor operative to analyze a first and a second breath waveform of said subject and provide at least one output depending on differences between said first and said second breath waveforms; and

a respiration diagnosis generator providing an indication of the respiratory status of said subject based on said at least one output of said breathing analyzer.

11. Apparatus according to claim 10 and wherein said at least one output depending on differences between said first and said second breath waveforms is processed by a trend analyzer, operative to compare said at least one output, with predefined changes with time in time-sequenced waveforms typical of patients with known respiratory deficiencies.