Pharmaceutical formulation comprising omeprazole

  • US 6,428,810 B1
  • Filed: 02/04/2000
  • Issued: 08/06/2002
  • Est. Priority Date: 11/05/1998
  • Status: Expired due to Term
First Claim
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1. An enteric coated oral pharmaceutical formulation comprising:

  • (a) a core material which comprises an active ingredient selected from the group consisting of omeprazole, an alkaline salt of omeprazole, one of the single enantiomers of omeprazole and an alkaline salt of one of the single enantiomers of omeprazole;

    (b) a separating layer; and

    (c) an enteric coating layer, wherein the separating layer comprises a hydroxypropyl cellulose (HPC) with a cloud point of at least 38°

    C., and wherein the light transmission at cloud point of a system comprising the HPC dissolved in a concentration of 1.0% (w/w) in a mixed solution of disodium hydrogen phosphate buffer 0.086 M and hydrochloric acid 0.1 M in the proportions 7;

    3 at a pH of 6.75-6.85 is 96%.

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