Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension

  • US 6,429,226 B1
  • Filed: 05/01/2000
  • Issued: 08/06/2002
  • Est. Priority Date: 09/06/1988
  • Status: Expired due to Fees
First Claim
Patent Images

1. A therapeutic composition for topical treatment of glaucoma or ocular hypertension in humans containing a prostaglandin PGA, PGB, PGE or PGF in an amount sufficient to reduce intraocular pressure without causing substantial ocular irritation and an ophthalmologically compatible vehicle,wherein the omega chain of the prostaglandin has the formula C13

  • B—

    C14

    D—

    R2 wherein C is a carbon atom (the number according to standard prostaglandin nomenclature being indicated by the subscript);

    B is a single bond or double bond;

    D is a subchain of 3 carbon atoms, having a hydroxyl group substituent; and

    R2 is 17-phenyl which is urnsubstituted or has at least one substituent selected from the group consisting of C1-C5 alkyl groups, C1-C4 alkoxy groups, trifluoromethyl groups, C1-C3 aliphatic acylamino groups, nitro groups, and a phenyl group.

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