Biosensors utilizing ligand induced conformation changes
First Claim
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1. A method of detecting the presence of a target analyte comprising:
- a) binding a target analyte to a binding ligand comprising at least a first electron donor moiety and a second electron acceptor moiety; and
b) detecting electron transfer between said donor and said acceptor, wherein there is a change in the amount of electron transfer between said donor and acceptor as a result of altering the structured state of said donor and acceptor, said altering induced by a conformational change in said binding ligand upon binding of said target analyte.
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Abstract
A method for detecting the presence of a target analyte comprising binding a target analyte to a binding ligand comprising at least a first electron donor moiety and a second electron acceptor moiety; and detecting the electron transfer between the donor and acceptor, wherein there is a change in the amount of electron transfer between the donor and acceptor as a result of altering the structured state of the donor and acceptor caused by a conformational change in the binding ligand upon binding of the target ligand.
93 Citations
4 Claims
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1. A method of detecting the presence of a target analyte comprising:
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a) binding a target analyte to a binding ligand comprising at least a first electron donor moiety and a second electron acceptor moiety; and
b) detecting electron transfer between said donor and said acceptor, wherein there is a change in the amount of electron transfer between said donor and acceptor as a result of altering the structured state of said donor and acceptor, said altering induced by a conformational change in said binding ligand upon binding of said target analyte. - View Dependent Claims (2, 3, 4)
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Specification
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Current AssigneeOsmetech Technology Inc. (Roche Holding AG)
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Original AssigneeClinical Micro Sensors Inc. (Roche Holding AG)
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InventorsPlaxco, Kevin W., Kayyem, Jon Faiz
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Primary Examiner(s)Chin, Christopher L.
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Application NumberUS09/489,459Time in Patent Office935 DaysField of Search204/400, 204/403, 422/82.01, 422/82.02, 422/82.03, 435/6, 435/7.1, 435/287.1, 435/287.2, 436/149, 436/151, 436/518, 436/536, 436/537, 436/806US Class Current436/518CPC Class CodesB82Y 30/00 Nanotechnology for material...G01N 2458/30 Electrochemically active la...G01N 33/532 Production of labelled immu...G01N 33/5438 ElectrodesG01N 33/582 with fluorescent labelY10S 436/806 Electrical property or magn...
