Determination of glucose concentration in tissue

• US 6,434,409 B1
• Filed: 06/06/2000
• Issued: 08/13/2002
• Est. Priority Date: 05/09/1996
• Status: Expired due to Fees

• Current Assignee: Roche Diagnostics GmbH (Roche Holding AG)
• Original Assignee: Roche Diagnostics GmbH (Roche Holding AG)
• Inventors: Hoss, Udo, Pfeiffer, Margret
• Primary Examiner(s): Shaver, Kevin
• Assistant Examiner(s): Natnithithadha, Navin
• Application Number:
  US09/588,231
• Time in Patent Office: 798 Days
• Field of Search: 600/347, 600/345, 600/348, 600/352, 600/354, 600/365, 600/366, 600/368
• US Class Current: 600/347
• CPC Class Codes: A61B 5/14528 invasively
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61B 5/7207 of noise induced by motion artifacts

Abstract

The present invention concerns a method for determining and monitoring tissue glucose concentration. Additionally, the present invention concerns a measuring apparatus to determine and monitor glucose concentration.

Claims

1. Measuring apparatus to determine and monitor tissue glucose concentration, comprising a microdialysis probe (12) implantable into the tissue (10) and being loadable at its inlet side through a perfusate line (21) with a perfusion solution (18) and being connected at its outlet side through a dialysate line (22) to an flow through test cell (14), and conveyor unit (26) mounted in the perfusate or dialysate line to move the perfusion solution through the microdialysis probe (12) to the test cell (14), characterized by at least one reservoir (20) containing dissolved glucose in a predetermined initial concentration and connected to the perfusate line (21).

2. Measuring apparatus as claimed in claim 1, characterized by two glucose reservoirs connected to the perfusate line and containing dissolved glucose of a concentration different from that of the other.

3. Measuring apparatus as claimed in claim 1, characterized in that the at least one reservoir (20) containing glucose can be connected through a switching valve to the perfusate line (21).

4. Measuring apparatus as claimed in claim 1, characterized in that the conveyor unit is preferably a metering pump (26) which can be operated in intermittent manner.