Sensor for measuring a bioanalyte such as lactate

• US 6,464,849 B1
• Filed: 10/07/1999
• Issued: 10/15/2002
• Est. Priority Date: 10/07/1999
• Status: Expired due to Term

• Current Assignee: Pepex Biomedical, Inc.
• Original Assignee: Pepex Biomedical, LLC
• Inventors: Tomasco, Michael F., Say, James L., Sakslund, Henning
• Primary Examiner(s): Warden, Jill
• Assistant Examiner(s): NOGUEROLA, ALEXANDER STEPHAN
• Application Number:
  US09/414,060
• Time in Patent Office: 1,104 Days
• Field of Search: 204/403, 204/416, 204/403.01, 204/403.14, 204/403.15
• US Class Current: 204/403.14
• CPC Class Codes: A61B 17/02 for holding wounds open; Tractors specula A61B1/32 ; drainage appliances for wounds A61M27/00
• CPC Class Codes: C12Q 1/004 mediator-assisted

Abstract

The present disclosure relates to a sensor including a bundle of electrically conductive fibers. The sensor also includes a sensing material coating at least some of the fibers in the bundle, and an insulating layer that surrounds the bundle of electrically conductive fibers.

Claims

1. A sensor comprising:

a bundle of electrically conductive fibers having a desired bundle diameter;

voids between the fibers for allowing analyte to diffuse into the sensor;

a dry sensing material that is reactive with the analyte, the dry sensing material coating at least some of the fibers in the bundle; and

an insulating layer surrounding the bundle of electrically conductive fibers.

2. The sensor of claim 1, wherein the insulating layer forms an analyte barrier that surrounds the bundle of conductive fibers.

3. The sensor of claim 2, wherein the analyte barrier defines at least one opening for allowing an analyte to access the sensing material.

4. The sensor of claim 1, wherein the insulating layer comprises an electrical insulator.

5. The sensor of claim 1, wherein the insulating layer comprises polyurethane.

6. The sensor of claim 1, wherein the conductive fibers comprise carbon.

7. The sensor of claim 1, wherein the sensing material includes a redox compound.

8. The sensor of claim 7, wherein the redox compound comprises a transition metal complex with one or more organic ligands.

9. The sensor of claim 7, wherein the sensing material includes a redox enzyme.

10. The sensor of claim 9, wherein the redox enzyme catalyzes the oxidation or reduction of an analyte.

11. The sensor of claim 10, wherein the analyte comprises lactate.

12. The sensor of claim 11, wherein the redox enzyme is selected from the group of lactate oxidize and lactate dehydrogenase.

13. The sensor of claim 10, wherein the analyte comprises glucose.

14. The sensor of claim 13, wherein the redox enzyme is selected from the group of glucose oxidize and glucose dehydrogenase.

15. The sensor according to claim 1, wherein the sensing material comprises a redox compound comprising an osmium transition metal complex with one or more organic ligands.