Lancet for capillary puncture blood samples

• US 6,468,287 B1
• Filed: 10/29/1998
• Issued: 10/22/2002
• Est. Priority Date: 04/30/1996
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Baugh, Robert F.
• Primary Examiner(s): Manuel, George
• Assistant Examiner(s): QADERI, RUNA S
• Application Number:
  US09/308,414
• Time in Patent Office: 1,454 Days
• Field of Search: 606/181-183, 604/266, 600/583, 600/576
• US Class Current: 606/181
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/150427 Specific tip design, e.g. for improved penetration characteristics
• CPC Class Codes: A61B 5/150511 Details of construction of shaft
• CPC Class Codes: A61B 5/150755 Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
• CPC Class Codes: A61B 5/15105 Purely manual piercing, i.e. the user pierces the skin without the assistance of any driving means or driving devices
• CPC Class Codes: A61B 5/15142 Devices intended for single use, i.e. disposable

Abstract

A piercing instrument (12) for obtaining a non-activated drop of blood (B) by capillary puncture is formed by depositing a coating agent (20) on the exterior surface of the piercing instrument (12). The coating agent comprises compounds that inhibit the activation of blood.

Claims

1. A lancet for obtaining a drop of blood for analysis by capillary puncture comprising a needle having an exterior surface that is adapted to puncture skin and a removable coating on said exterior surface wherein the portion of said coating that comes in contact with a puncture site obtained by capillary puncture with said needle is transferred from said needle to said puncture site, said coating comprising a composition which inhibits contact activation of the drop of blood at said puncture site.

2. A lancet as defined in claim 1, wherein said coating further comprises a material that is capable of inhibiting fibrinolysis.

3. A lancet as defined in claim 1, wherein said coating further includes a material that is capable of inhibiting platelet activation of said drop of blood.

4. An apparatus for obtaining blood samples by capillary puncture comprising a lancet and a removable coating on the surface of said lancet wherein the portion of said coating that comes in contact with a puncture site obtained by capillary puncture with said lancet is transferred from said lancet to said puncture site, said coating including a blood platelet inhibitor, a serine protease inhibitor, and a monoclonal antibody to thromboplastin.

5. An apparatus as defined in claim 4, wherein said serine protease inhibitor is aprotinin.

6. An apparatus as defined in claim 4, wherein said composition further comprises a bacteriostatic or bactericidal agent.

7. An apparatus as defined in claim 4, wherein said composition further comprises an analgesic compound.

8. An apparatus for inhibiting contact activation of blood, comprising an instrument adapted to puncture a bodily tissue and having an exterior surface coated with a removable composition, wherein the portion of said coating that comes in contact with a puncture site obtained by capillary puncture with said instrument is transferred from said instrument to said puncture site, said composition comprising one or more compounds that specifically inhibit one or more blood activation mechanisms at the puncture site.

9. The apparatus of claim 8, wherein one or more of said compounds specifically inhibits one or more blood activation mechanism.

10. The apparatus of claim 9, wherein said composition comprises a blood platelet inhibitor, a serine protease inhibitor, and an antibody to thromboplastin.

11. The apparatus of claim 10, wherein said composition further comprises an analgesic.

12. The apparatus of claim 10, wherein said composition further comprises a bacteriostatic or bactericidal agent.

13. The apparatus of claim 8, wherein said composition comprises a compound that inhibits contact activation of the intrinsic coagulation system.

14. The apparatus of claim 8, wherein said composition comprises a compound that inhibits fibrinolysis activation by contact activation.

15. The apparatus of claim 8, wherein said composition comprises a compound that inhibits platelet activation by connective tissue.

16. The apparatus of claim 8, wherein said composition comprises a compound that inhibits tissue factor activation of extrinsic coagulation.

17. A method of obtaining a drop of blood for analysis, comprising the steps of:

coating an outside surface of a lancet with a removable composition that inhibits contact activation of the drop of blood; and

puncturing a bodily tissue with said outside surface of said lancet to obtain the drop of blood, wherein the portion of said composition that comes in contact with said bodily tissue is transferred from said lancet to said puncture site.

18. The method of claim 17, wherein said composition includes a compound that inhibits fibrinolysis activation by contact activation.

19. The method of claim 18, wherein said composition includes a serine protease inhibitor.

20. The method of claim 17, wherein said composition includes a compound that inhibits platelet activation by connective tissue.

21. The method of claim 20, wherein said compound is a prostacylin analog.

22. The method of claim 17, wherein said composition includes a compound that inhibits tissue factor activation of extrinsic coagulation.

23. The method of claim 17, wherein said composition inclides a compound that inhibits contact activation of the intrinsic coagulation system.

24. The method of claim 17, wherein said composition prevents contact activation of the drop of blood at the site of the punctures bodily tissue.

25. A method for obtaining a non-activated drop of blood comprising:

coating a surface of an instrument with a removable composition comprising a serine protease inhibitor, a blood platelet inhibitor, and a monoclonal antibody to thromboplastin; and

puncturing a bodily tissue with said instrument, thereby transferring the portion of said composition that comes in contact with the puncture site from said instrument to the puncture site wherein said serine protease inhibitor, said blood platelet inhibitor, and said monoclonal antibody inhibit one or more blood activation mechanisms.

26. An improved lancet for obtaining a drop of blood for analysis by capillary puncture of a bodily tissue, wherein the improvement comprises said lancet having a removable coating thereon of a composition which precludes contact activation, platelet activation, and fibrinolysis of the blood sample, wherein the portion of said coating that comes in contact with a bodily tissue is transferred from said lancet to the puncture site.

27. An improved lancet as defined in claim 26, wherein said composition includes a serine protease inhibitor or analogues thereof.

28. An improved lancet as defined in claim 27, wherein said serine protease inhibitor is aprotinin.

29. An improved lancet as defined in claim 26, wherein said composition includes an antiplatelet compound.

30. An improved lancet as defined in claim 29, wherein said antiplatelet compound is prostacyclin.