Ureapoietic organ replacement

• US 6,468,312 B1
• Filed: 04/09/2001
• Issued: 10/22/2002
• Est. Priority Date: 07/26/1998
• Status: Expired due to Fees

• Current Assignee: Albert Scheller, Klaus Rennebeck
• Original Assignee: Albert Scheller, Klaus Rennebeck
• Inventors: Scheller, Albert, Rennebeck, Klaus
• Primary Examiner(s): Willse, David H.
• Assistant Examiner(s): GHERBI, SUZETTE JAIME J
• Application Number:
  US09/744,516
• Time in Patent Office: 561 Days
• Field of Search: 623/23-4-, 623/23-2-, 435/180
• US Class Current: 623/23.64
• CPC Class Codes: A61M 1/1678 intracorporal peritoneal dialysis A61M1/28
• CPC Class Codes: A61M 1/3472 with treatment of the filtrate
• CPC Class Codes: A61M 1/3489 by biological cells, e.g. bioreactor

Abstract

The invention relates to a bionic organ replacement which has a structure consisting of three groups of textile hollow microfibers. The hollow microfibers of each group run into in a liquid conductor which is central respectively. The hollow microfibers of the first group (1) are made from a proton-conducting material and have perforations (2) for draining bile into the area inside the fibers (1). One of the surfaces in essentially every hollow microfiber (1) of the first group (1) is hydrophilic and lipophilic whilst the other surface is hydrophobic and lipophobic. Cell cultures can be grown on the outer surfaces of all of the hollow microfibers.

Claims

1. Bionic organ replacement, presenting a structure of three groups of textile hollow micro fibers, whereby the hollow micro fibers of each group issue into a respectively central liquid conductor,

wherein the hollow micro fibers (1) of the first group are made of proton-conducting material and present perforations (2) for the drainage of bile liquid into the interior of the fibers (1) and the one of the surfaces of essentially each hollow micro fiber (1) of the first group is hydrophilic and lipophilic, while the other of the surfaces is hydrophobic and lipophobic and,

wherein cell cultures can be grown on the outer surfaces of all of the hollow micro fibers.

2. Bionic organ replacement, comprising a structure of three groups of textile hollow micro fibers, whereby the hollow micro fibers of each group issue into a respectively central liquid conductor, whereby cell cultures can be grown of the outer surfaces of all of the hollow micro fibers,

characterized in that the hollow micro fibers (1) of the first group are made of proton-conductive material and present perforations (2) for the drainage of bile liquid into the interior of the fibers (1) and the surfaces-of essentially each hollow micro fiber (1) of the first group are hydrophilic and lipophilic, while the other of the surfaces is hydrophobic and lipophobic.

3. Bionic organ replacement according to claim 2, characterized in that the outer surfaces of the hollow micro fibers are fully overgrown with human liver cells, cultured in vitro.

4. Bionic organ replacement according to claim 3, characterized in that the hollow micro fibers have an inner diameter of approximately 0.1 to 50 μ

m.

5. Bionic organ replacement according to claim 3, characterized in that the hollow micro fibers are arranged, in cross-section, in a honey-comb shaped structure.

6. Bionic organ replacement according to claim 3, characterized in that the liquid conductor is compatible with the structure of the corresponding human vessel.

7. Bionic organ replacement according to claim 3, characterized in that the number and size of the perforations (2) is designed in such manner that a bile flow is possible of approximately 100 to 3000 ml/d.

8. Bionic organ replacement according to claim 2, characterized in that the hollow micro fibers have an inner diameter of approximately 0.1 to 50 μ

m.

9. Bionic organ replacement according to claim 8, characterized in that the hollow micro fibers are arranged, in cross-section, in a honey-comb shaped structure.

10. Bionic organ replacement according to claim 8, characterized in that the liquid conductor is compatible with the structure of the corresponding human vessel.

11. Bionic organ replacement according to claim 8, characterized in that the number and size of the perforations (2) is designed in such manner that a bile flow is possible of approximately 100 to 3000 ml/d.

12. Bionic organ replacement according to claim 2, characterized in that the hollow micro fibers are arranged, in cross-section, in a honey-comb shaped structure.

13. Bionic organ replacement according to claim 12, characterized in that the liquid conductor is compatible with the structure of the corresponding human vessel.

14. Bionic organ replacement according to claim 12, characterized in that the number and size of the perforations (2) is designed in such manner that a bile flow is possible of approximately 100 to 3000 ml/d.

15. Bionic organ replacement according to claim 2, characterized in that the liquid conductor is compatible with the structure of the corresponding human vessel.

16. Bionic organ replacement according to claim 15, characterized in that the number and size of the perforations (2) is designed in such manner that a bile flow is possible of approximately 100 to 3000 ml/d.

17. Bionic organ replacement according to claim 2, characterized in that the number and size of the perforations (2) is designed in such manner that a bile flow is possible of approximately 100 to 3000 ml/d.