Biocompatible adhesives

• US 6,468,660 B2
• Filed: 12/29/2000
• Issued: 10/22/2002
• Est. Priority Date: 12/29/2000
• Status: Expired due to Term

• Current Assignee: St Jude Medical Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: St Jude Medical Incorporated (Abbott Laboratories Incorporated)
• Inventors: Ogle, Matthew F., McConico, Andrea L.
• Primary Examiner(s): Dawson, Robert
• Assistant Examiner(s): Keehan, Christopher M.
• Application Number:
  US09/751,963
• Publication Number:
  US 20020122944A1
• Time in Patent Office: 662 Days
• Field of Search: 428/413, 524/9, 524/10, 524/14, 524/21, 623/2.1, 11/11
• US Class Current: 428/413
• CPC Class Codes: A61L 24/046 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043 takes precedence
• CPC Class Codes: C08L 63/00 Compositions of epoxy resins; Compositions of derivatives of epoxy resins
• CPC Class Codes: C09J 163/00 Adhesives based on epoxy resins; Adhesives based on derivatives of epoxy resins
• CPC Class Codes: Y10T 428/31511 Of epoxy ether
• CPC Class Codes: Y10T 428/31515 As intermediate layer

Abstract

Novel adhesive compositions are described that include an epoxyamine and, preferably, a curing agent. The adhesive composition can be used in surgical settings such as implanting bioprostheses and/or in manufacturing of bioprostheses. Biocompatible substrates can be adhered together by an adhesive bond formed by curing of the epoxyamine adhesive composition.

Claims

1. An adhesive composition comprising an epoxyamine and a curing agent, wherein the epoxyamine is at a concentration of between about 25 percent by weight and about 90 percent by weight, wherein the adhesive composition is biocompatible.

2. The adhesive composition of claim 1 wherein an adhesive bond is formed when the adhesive composition is associated with a first substrate and joined to a second substrate.

3. The adhesive composition of claim 1 wherein the epoxyamine is triglycidyl amine.

4. The adhesive composition of claim 1 wherein the curing agent comprises a functional group selected from the group consisting of sulfur-containing functional groups, nitrogen-containing functional groups and oxygen-containing functional groups.

5. The adhesive composition of claim 1 wherein the curing agent comprises a functional group selected from the group consisting of a thiol, an alcohol and an amine.

6. The adhesive composition of claim 1 wherein the adhesive composition further comprises a flexibilizer.

7. The adhesive composition of claim 6 wherein the flexibilizer is selected from the group consisting of collagen, albumin, glycosaminoglycans and combinations thereof.

8. The adhesive composition of claim 2 wherein the adhesive bond is formed after at least about one minute.

9. The adhesive composition of claim 1 wherein the curing agent is between about 1 percent by weight and about 20 percent by weight of the adhesive composition.

10. The adhesive composition of claim 6 wherein the flexibilizer is between about 1 percent by weight and about 40 percent by weight of the adhesive composition.

11. The adhesive composition of claim 1 further comprising a biological response modifier.

12. The adhesive composition of claim 11 wherein the biological response modifier comprises transforming growth factor-beta.

16. The adhesive composition of claim 1, wherein the epoxyamine comprises a plurality of different epoxyamine compounds.

17. The adhesive composition of claim 1, wherein the composition further comprises a resorbable composition.

18. The adhesive composition of claim 1, wherein the adhesive composition further comprises a solvent.

19. The adhesive composition of claim 18, wherein the solvent comprises water.

20. The adhesive composition of claim 19, wherein the solvent further comprises a buffer.

21. The adhesive composition of claim 19, wherein the adhesive composition further comprises salt.

22. The adhesive composition of claim 1, wherein the adhesive composition further comprises a softening agent.

23. The adhesive composition of claim 11, wherein the biological response modifier comprises an antimicrobial agent.

24. The adhesive composition of claim 11, wherein the biological response modifier comprises an anticalcification agent.

25. The adhesive composition of claim 2, wherein the fist substrate and the second substrate are native tissue.

26. A prosthesis, wherein the prosthesis comprises a first substrate and a second substrate, wherein the first substrate and the second substrate are adhered by the adhesive composition of claim 1.

13. A medical adhesive comprising an adhesive composition and transforming growth factor-beta wherein the adhesive composition comprises an epoxyamine.

14. A medical device having two substrates secured with a cured form of the adhesive of claim 13.

15. The medical device of claim 14 wherein the medical device is an implantable prosthesis.

27. The medical adhesive of claim 13, wherein the adhesive composition further comprises a curing agent.

28. The medical adhesive of claim 27, wherein the curing agent is between about 1 percent by weight and about 20 percent by weight of the adhesive composition.

29. The medical adhesive of claim 13, wherein the epoxyamine comprises triglycidylamine.