Methods of pretreating hyperlipidemic individuals with a flush inhibiting agent prior to the start of single daily dose nicotinic acid therapy to reduce flushing provoked by nicotinic acid

  • US 6,469,035 B1
  • Filed: 07/31/1997
  • Issued: 10/22/2002
  • Est. Priority Date: 07/31/1997
  • Status: Expired due to Term
First Claim
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1. A method of reducing the capacity of extended release nicotinic acid to provoke a flushing reaction in an individual when extended release nicotinic acid is orally administered in an effective lipid-altering amount as a single dose once a day during the evening hours or before or at bedtime, comprisingorally pretreating the individual with an effective flush inhibiting amount of a flush inhibiting agent for a sufficient period of time prior to initiating the administration of the extended release nicotinic acid in the individual to inhibit or reduce prostaglandin PGD2 induced by the extended release nicotinic acid;

  • and orally administering the nicotinic acid to the pretreated individual in an effective lipid-altering amount as a single dose once a day during the evening hours or before or at bedtime without causing treatment-limiting hepatotoxicity and elevations in glucose and/or uric acid levels, whereby the capacity of the extended release nicotinic acid to provoke a flushing reaction in the pretreated individual is reduced or prevented.

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