Imaging system with a cylindrical lens array

• US 6,473,239 B2
• Filed: 04/12/2001
• Issued: 10/29/2002
• Est. Priority Date: 10/12/1998
• Status: Expired due to Fees

• Current Assignee: Carl-Leiss-Stiftung Trading AS Carl Zeiss
• Original Assignee: Carl-Zeiss-Stiftung
• Inventors: Fattinger, Christof, Völcker, Martin
• Primary Examiner(s): Epps, Georgia
• Assistant Examiner(s): Spector, David N.
• Application Number:
  US09/835,172
• Publication Number:
  US 20020030894A1
• Time in Patent Office: 565 Days
• Field of Search: 250/206.1, 250/216, 250/486.1, 250/576, 356/123, 356/127, 356/141, 356/621, 356/622, 356/623, 356/624, 356/639, 356/640, 359/710
• US Class Current: 359/624
• CPC Class Codes: G01N 21/253 for batch operation, i.e. multisample apparatus analytical automats G01N35/00
• CPC Class Codes: G01N 21/6452 Individual samples arranged in a regular 2D-array, e.g. multiwell plates
• CPC Class Codes: G01N 2201/024 Modular construction
• CPC Class Codes: G02B 3/005 arranged along a single direction only, e.g. lenticular sheets G02B3/0043 takes precedence
• CPC Class Codes: G02B 3/0068 arranged in a single integral body or plate, e.g. laminates or hybrid structures with other optical elements G02B5/1885, G02B17/002, G02B30/27 take precedence
• CPC Class Codes: G02B 5/045 Prism arrays

Abstract

The invention relates to an imaging system for optical automatic analysers, especially fluorescence readers. On the sample side, the imaging system contains a cylindrical lens array and a prism array, which is arranged upstream of the cylindrical lens array. The prismatic effect of the prisms of the prism array lies in the direction of the cylinder axes of the cylindrical lenses. Together with a telescopic imaging system, the inventive imaging system creates a number of parallel cylindrical focussing volumes between the cylindrical lens array and a detector array, these focussing volumes being slanted towards the optical axis of the telescopic system in relation to the vertical. The arrangement enables the detection of fluorescence with a large aperture in one direction, and at the same time enables depth selective analysis of the fluorescence signal, especially the discrimination of the fluorescent radiation originating from the solution above.

Claims

1. Imaging system with an array (6) of cylindrical lenses (6a, 6b, 6c) and with a prism array (7) combined with, or arranged before, the array of cylindrical lenses, wherein the prismatic effect of the prisms (7a, 7b, 7c) is in the direction of the cylinder axes of the cylindrical lenses (6a, 6b, 6c), so that the cylinder axes of the substantially cylindrical focal volumes of the cylindrical lenses receive an inclination relative to the cylinder axes of the cylindrical lenses.

2. Imaging system according to claim 1, wherein a detector array (10) and a telescopic imaging system are provided, wherein the telescope imaging system is arranged between the array (6) of cylindrical lenses (6a, 6b, 6c) and the detector array (10) and wherein the prism array (7) is arranged on the side of the array (6) of cylindrical lenses (6a, 6b, 6c) remote from the telescopic image system.

3. Imaging system according to claim 2, wherein the long-focus lens (8) of the telescopic imaging system is arranged adjoining the array (6) of cylindrical lenses (6a, 6b, 6c), and its diameter overlaps several cylindrical lenses (6a, 6b, 6c).

4. Imaging system according to claim 2, wherein the detector array (10) is arranged behind the exit-side focal plane (F2) of the telescope lens (11) remote from the cylindrical lens array (6).

5. Imaging system according to claim 2, wherein the apertures of the cylindrical lenses (6a, 6b, 6c) are imaged on the detector array (10) by means of the telescopic imaging system (8, 11).

6. Imaging system according to claim 1, wherein the cylindrical lens array (6) and/or the prism array (7) are strip-shaped.

7. Imaging system according to claim 2, wherein a vertical illuminator (12) is provided which is reflected between the detector array (10) and the short-focus lens of the telescopic imaging system into the beam path leading into the array (6) of cylindrical lenses (6a, 6b, 6c).

8. Automatic analyzer with an optical imaging system according to claim 2, wherein an evaluation of the optical signals detected with the detector array (10).

9. Imaging system of modular construction, consisting of:

a first constructional unit (1) with an array of cylindrical lenses and a prism array combined with, or arranged before, the array of cylindrical lenses, wherein the prismatic effect of the prisms (7a, 7b, 7c) is in the direction of the cylinder axes of the cylindrical lenses (6a, 6b, 6c),

a second constructional unit with a long-focus optics (8), the free usable aperture diameter of which overlaps the diameter of the cylindrical lens array (6),

a third constructional unit (4) with a short-focus optics (11), which in common with the long-focus optics (8) of the second constructional unit forma an afocal system, and

a fourth constructional unit (3) without imaging optics, arranged between the second constructional unit (2) and the third constructional unit (4).

10. Imaging system of modular construction according to claim 9, wherein two further constructional units (31, 33) are provided, of which the one is an array (32) with rotationally symmetrical individual lenses (32a-32c) for interchange with the first constructional unit (1), and the second additional constructional unit (33) has a field lens (34) and is interchangeable with the fourth constructional unit.