Method for inhibiting increase of blood sugar level or lowering blood sugar level with a lagerstroemia extract

• US 6,485,760 B2
• Filed: 11/10/1999
• Issued: 11/26/2002
• Est. Priority Date: 12/09/1998
• Status: Expired due to Fees

• Current Assignee: Futoshi Matsuyama
• Original Assignee: Futoshi Matsuyama
• Inventors: Matsuyama, Futoshi
• Primary Examiner(s): Brusca, John S.
• Assistant Examiner(s): Moran, Marjorie A.
• Application Number:
  US09/437,342
• Publication Number:
  US 20010006941A1
• Time in Patent Office: 1,112 Days
• Field of Search: 424/195.1, 424/775, 514/693, 514/766, 514/763, 536/1.11
• US Class Current: 424/775
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics

Abstract

A composition for inhibiting an increase in, or lowering, a blood sugar level, which comprises, as a main component, a concentrate of a hot water or alcohol extract of leaves of Lagerstroemia Speciosa, Linn. or Pers. and has an corosolic acid content of 0.01 to 15 mg per 100 mg of the concentrate, and a method of inhibiting an increase in, or lowering, a blood sugar level by oral administration of the composition.

Claims

1. A method of inhibiting an increase in blood sugar level in a human patient who is expected to suffer an increase in blood sugar level, which comprises orally administering to said patient an active ingredient containing concentrate consisting essentially of ethanol or ethanol aqueous solution extract of leaves of Langerstroemia Speciosa, Linn. or Pers., said concentrate having a corosolic acid content of 0.1 to 15 mg per 100 mg of the concentrate, said concentrate being administered at a dose of 50 mg to 1,000 mg per kg of body weight of said patient per day, which is effective to inhibit an increase in blood sugar level in said patient.

2. The method according to claim 1, which comprises administering the concentrate to said patient twice daily.

3. The method according to claim 1, which comprises administering the concentrate to said patient three times daily.

4. The method according to claim 1, which comprises administering the concentrate in the form of a tablet.

5. The method according to claim 1, which comprises administering the concentrate in the form of powder or granules.

6. The method according to claim 1, wherein said concentrate has a corosolic acid content of from 0.2 to 12 mg, per 100 mg of the concentrate.

7. The method according to claim 1, wherein said concentrate has a corosolic acid content of from 0.5 to 10 mg, per 100 mg of the concentrate.

8. The method according to claim 1, wherein the concentrate is orally administered at a dose of from 70 to 800 mg per kg of body weight.

16. The method according to claim 1, wherein said ethanol aqueous solution contains 50 to 80% by weight of ethanol.

9. A method of lowering blood sugar level to normal level in a human diabetes patient having a blood sugar level above normal blood sugar level, which comprises orally administering to said diabetes patient an active ingredient containing concentrate consisting essentially of ethanol or ethanol aqueous solution extract of leaves of Lagerstroemia Speciosa, Linn. or Pers., said concentrate having a corosolic acid content of 0.1 to 15 mg per 100 mg of the concentrate, said concentrate being administered at a dose of 50 mg to 1,000 mg per kg of body weight of said patient per day, which is effective to lower blood sugar level to a normal level in said diabetes patient.

10. The method according to claim 9, which comprises administering the concentrate to said patient twice daily.

11. The method according to claim 9, which comprises administering the concentrate to said patient three times daily.

12. The method according to claim 10, wherein said concentrate has a corosolic acid content of from 0.2 to 12 mg, per 100 mg of the concentrate.

13. The method according to claim 9 wherein said concentrate has a corosolic acid content of from 0.5 to 10 mg, per 100 mg of the concentrate.

14. The method according to claim 9, which comprises administering the concentrate in the form of a tablet.

15. The method according to claim 9, which comprises administering the concentrate in the form of powder or granules.

17. The method according to claim 9, wherein said ethanol aqueous solution contains 50 to 80% by weight of ethanol.