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Non-invasive transdermal detection of analytes

  • US 6,492,180 B2
  • Filed: 06/24/1999
  • Issued: 12/10/2002
  • Est. Priority Date: 06/24/1998
  • Status: Expired due to Fees
First Claim
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1. A method for the noninvasive transdermal detection of analytes present within a mammalian subject, comprising:

  • contacting the skin of said subject with a pyrrolidone of the following formula in aqueous admixture, embedded image

    wherein R1=H, CH3

    , HO—

    CH2

    CH2

    , CH3

    CH2

    , or CH3

    (CH2)n

    , wherein n=1 to 11, R3=H, —

    OH, CH3

    , or CH3

    (CH2)n

    , wherein n=1 to 11, R4=H, or methyloxycarbonyl, and R5=H, CH3

    , CH3

    CH2

    , or HO—

    CH2

    CH2, for a time, no longer than 2 hours, sufficient to permit detectable amounts of said analyte to be extracted from said subject into said aqueous pyrrolidone mixture; and

    then detecting said extracted analyte, wherein said analyte is a heavy metal.

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