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Fast dispersing dosage forms essentially free of mammalian gelatin

  • US 6,509,040 B1
  • Filed: 06/22/2001
  • Issued: 01/21/2003
  • Est. Priority Date: 06/22/2001
  • Status: Active Grant
First Claim
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1. A fast dispersing solid dosage form designed to release an active ingredient rapidly in the oral cavity characterized in that said dosage form is essentially free of mammalian gelatin and comprises:

  • a) at least one active ingredient;

    b) at least one modified starch at a concentration of from 20 to 90% by weight;

    selected from the group consisting of starches whose hydroxyl groups have been esterified, hydroxypropyl di-starch phosphate, an enzymatically modified starch, a pregelatinized di-starch phosphate, hydroxyethyl starch, a pregelatinized acetylated di-starch phosphate and a pregelatinized purified starch; and

    c) at least one matrix forming agent;

    wherein said solid dosage form has a disintegration/dispersion time of from 1-60 seconds and is obtainable by removing a solvent from a mixture comprising said active ingredient, said modified starch and said matrix forming agent.

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