Method and apparatus for the noninvasive determination of arterial blood pressure

• US 6,514,211 B1
• Filed: 01/21/2000
• Issued: 02/04/2003
• Est. Priority Date: 06/29/1999
• Status: Expired due to Fees

• Current Assignee: Tensys Medical Inc. (Recorders & Medicare Systems Pvt Ltd.)
• Original Assignee: Tensys Medical Inc. (Recorders & Medicare Systems Pvt Ltd.)
• Inventors: Baura, Gail D.
• Primary Examiner(s): Nasser, Robert L.
• Application Number:
  US09/489,160
• Time in Patent Office: 1,110 Days
• Field of Search: 600/485, 600/490, 600/493-6, 600/500
• US Class Current: 600/490
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/489 Blood vessels
• CPC Class Codes: A61B 5/6806 Gloves
• CPC Class Codes: A61B 5/6843 Monitoring or controlling sensor contact pressure
• CPC Class Codes: A61B 5/7225 Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation A61B5/30, A61B5/316 take precedence; transformers for specific applications H01F38/00; amplifiers H03F
• CPC Class Codes: A61B 5/726 using Wavelet transforms
• CPC Class Codes: A61B 8/04 Measuring blood pressure
• CPC Class Codes: A61B 8/4227 characterised by straps, belts, cuffs or braces

Abstract

A method and apparatus for determining the mean arterial blood pressure (MAP) of a subject during tonometric conditions. In one embodiment, the apparatus comprises one or more pressure and ultrasound transducers placed over the radial artery of a human subject'"'"'s wrist, the latter transmitting and receiving acoustic energy so as to permit the measurement of blood velocity during periods of variable compression of the artery. During compression, the ultrasound velocity waveforms are recorded and processed using time-frequency analysis. The time at which the mean time-frequency distribution is maximal corresponds to the time at which the transmural pressure equals zero, and the mean pressure read by the transducer equals the mean pressure within the artery. In another aspect of the invention, the ultrasound transducer is used to position the transducer over the artery such that the accuracy of the measurement is maximized. In yet another aspect of the invention, a wrist brace useful for measuring blood pressure using the aforementioned apparatus is disclosed. A method of continuously estimating systolic and diastolic pressure is also described.

Claims

1. A method of continuously and non-invasively estimating the blood pressure existing within the artery of a subject, comprising:

estimating the diastolic pressure within said artery;

estimating the mean pressure within said artery;

sensing a pressure waveform from said artery;

deriving a scaling factor by modeling a mechanical impulse response of said artery as a mathematical function based at least in part on said estimated diastolic pressure and said estimated mean pressure; and

continuously estimating the blood pressure within said artery based on said scaling factor, said sensed pressure waveform, and said mean pressure.

2. The method of claim 1, wherein said act of modeling a mathematical function comprises modeling as a linear autoregression function.

3. The method of claim 2, wherein said act of modeling as a linear autoregression function comprises selecting the order of said autoregression function based at least in part on standard deviation and residuals.

4. A method of continuously and non-invasively estimating the blood pressure existing within the artery of a subject, comprising:

estimating the diastolic pressure within said artery;

estimating the mean pressure within said artery by;

(i) transmitting an acoustic signal into said artery;

(ii) receiving an echo from said acoustic signal;

(iii) analyzing said echo to estimate the velocity of said blood flowing in said artery;

(iv) forming a time-frequency representation of said velocity; and

(v) generating an estimate of mean blood pressure when said time-frequency representation satisfies a given condition;

sensing a pressure waveform from said artery;

deriving a scaling factor based at least in part on said estimated diastolic pressure and said estimated mean pressure; and

continuously estimating the blood pressure within said artery based on said scaling factor, said sensed pressure waveform, and said mean pressure.

5. The method of claim 4, wherein said given condition comprises maximization of said time-frequency representation.

6. A method of continuously and non-invasively estimating the blood pressure existing within the artery of a subject, comprising:

estimating a first pressure within said artery;

estimating a second pressure within said artery;

sensing a pressure waveform from said artery;

deriving a scaling factor by modeling a mechanical impulse response of said artery as a linear autoregression function based at least in part on said estimated first and second pressures; and

continuously estimating the blood pressure within said artery based on said scaling factor, said sensed pressure waveform, and said second pressure.

7. The method of claim 6, wherein said act of modeling as a linear autoregression function comprises selecting the order of said autoregression function based at least in part on standard deviation and residuals.

8. A method of continuously and non-invasively estimating the blood pressure existing within the artery of a subject, comprising:

estimating a first pressure within said artery;

estimating a second pressure within said artery, comprising;

transmitting an acoustic signal into and receiving an echo from said artery;

analyzing said echo to estimate the velocity of said blood flowing in said artery;

forming a time-frequency representation of said velocity; and

generating an estimate of said second pressure when said time-frequency representation satisfies a given condition;

sensing a pressure waveform from said artery;

deriving a scaling factor based at least in part on said estimated first and second pressures; and

continuously estimating the blood pressure within said artery based on said scaling factor, said sensed pressure waveform, and at least one of said first and second pressures.

9. The method of claim 8, wherein said given condition comprises maximization of said time-frequency representation.

10. Apparatus for continuously and non-invasively estimating the blood pressure existing within the artery of a subject, comprising:

a sensor adapted to detect a pressure waveform from said artery and generate electrical signals relating thereto;

a processor operatively coupled to said sensor and adapted to process said electrical signals, said processing of said signals comprising at least;

(i) estimating a first pressure within said artery;

(ii) estimating a second pressure within said artery;

(iii) deriving a scaling factor by modeling a mechanical impulse response of said artery as a function based at least in part on said estimated first and second pressures; and

(iv) continuously estimating the blood pressure within said artery based on said scaling factor, said pressure waveform, and at least one of said first and second pressures.

11. Apparatus as defined in claim 10, wherein said act of modeling as a function comprises (i) modeling as a linear autoregression function;

and (ii) selecting the order of said autoregression function based at least in part on standard deviation and residuals.

12. Apparatus with means for continuously and non-invasively estimating the blood pressure existing within the artery of a subject, comprising:

means for detecting a pressure waveform from said artery, including means for generating electrical signals relating thereto;

processor means operatively coupled to said means for detecting for processing said electrical signals, said processing of said signals comprising at least;

(i) estimating a first pressure within said artery;

(ii) estimating a second pressure within said artery;

(iii) deriving a scaling factor by modeling a mechanical impulse response of said artery as a mathematical function based at least in part on said estimated first and second pressures; and

(iv) continuously estimating the blood pressure within said artery based on said scaling factor, said pressure waveform, and at least one of said first and second pressures.

13. Apparatus as defined in claim 12, wherein said act of modeling as a mathematical function comprises (i) modeling as a linear autoregression function, and (ii) selecting the order of said autoregression function based at least in part on standard deviation and residuals.

14. A method of continuously and non-invasively estimating the blood pressure existing within the artery of a subject, comprising the steps of:

estimating a first pressure within said artery;

estimating a second pressure within said artery;

sensing a pressure waveform from said artery;

modeling a mechanical impulse response of said artery as a mathematical function based at least in part on said estimated first and second pressures to derive a scaling factor; and

using said scaling factor, said sensed pressure waveform, and said second pressure to estimate continuously the blood pressure within said artery.

15. The method of claim 14, wherein said act of modeling as a mathematical function comprises (i) modeling as a linear autoregression function and (ii) selecting the order of said autoregression function based at least in part on standard deviation and residuals.