Subcutaneous glucose electrode

  • US 6,514,718 B2
  • Filed: 11/29/2001
  • Issued: 02/04/2003
  • Est. Priority Date: 03/04/1991
  • Status: Expired due to Fees
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First Claim
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1. A method of monitoring glucose levels in a human, in-vivo, the method comprising:

  • (1) subcutaneously implanting in a human, and placing in contact with a glucose-containing body fluid inside the human, a first electrochemical glucose sensor that produces substantially no signal output when the concentration of glucose is zero in the fluid;

    (2) determining a glucose level of the human using a second glucose sensor;

    (3) measuring a first electrical signal representative of glucose concentration in the fluid from the first sensor;

    (4) calibrating the first sensor using the first electrical signal and glucose level determined in step (2);

    (5) measuring additional electrical signals representative of glucose concentration in the fluid from the first sensor for a period of at least about 36 hours; and

    (6) determining glucose concentration based on the electrical signals measured in step (5) and calibration in step (4) without further calibration.

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