Heart rate variability as an indicator of exercise capacity
First Claim
1. A method of optimizing a mode of therapy applied to a patient, comprising the steps of:
- (a) measuring and recording ECG waveforms over a predetermined time interval at a first point in time;
(b) computing from said ECG waveforms the absolute value of the difference in the length of successive RR intervals;
(c) plotting a two-dimensional histogram of the values computed in step (b) vs. RR intervals;
(d) measuring the area subtended by the plot of step (c) as an indicator of a patient'"'"'s exercise capacity;
(e) subsequently changing the mode of therapy applied to the patient;
(f) repeating steps (a) through (d) at a later time;
(g) plotting a value of the area measured in step (d) at the first point in time and at the later time to display trends in the patient'"'"'s exercise capacity. (h) comparing the area measured in step (d) at the first point in time to the area measured in step (d) at the later time to assess which area is the greater; and
(i) adjusting the mode of therapy to increase the patient'"'"'s exercise capacity.
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Abstract
Based upon patient studies indices a high degree of correlation was found between HRV and VO2max, i.e., the patient'"'"'s exercise capacity. Based on this finding, a pacing therapy optimization protocol for treating patients with CHF has been devised. The protocol involves first pacing the patient'"'"'s heart with a pacemaker programmed to operate in a first mode for a predetermined time period and then collecting electrogram data from which a HRV index is derived. The mode is then changed and the steps repeated until all possible modes have been utilized. At that time, a determination is made as to which of the modes is associated with the largest HRV index and the pacemaker is then programmed to function in that mode. Alternatively, the method of the present invention can be applied to changes in drug therapy instead of or in combination with pacing therapy. By the plotting the HRV index computed in the manner described, the efficacy of a change in therapy on patient exercise capacity can be assessed.
254 Citations
1 Claim
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1. A method of optimizing a mode of therapy applied to a patient, comprising the steps of:
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(a) measuring and recording ECG waveforms over a predetermined time interval at a first point in time;
(b) computing from said ECG waveforms the absolute value of the difference in the length of successive RR intervals;
(c) plotting a two-dimensional histogram of the values computed in step (b) vs. RR intervals;
(d) measuring the area subtended by the plot of step (c) as an indicator of a patient'"'"'s exercise capacity;
(e) subsequently changing the mode of therapy applied to the patient;
(f) repeating steps (a) through (d) at a later time;
(g) plotting a value of the area measured in step (d) at the first point in time and at the later time to display trends in the patient'"'"'s exercise capacity. (h) comparing the area measured in step (d) at the first point in time to the area measured in step (d) at the later time to assess which area is the greater; and
(i) adjusting the mode of therapy to increase the patient'"'"'s exercise capacity.
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Specification