Compositions and methods for early detection of heart disease
First Claim
1. Composition for detecting at least one non-polypeptidic cardiac marker in a test sample obtained from a mammal, said composition comprising at least one moiety that specifically binds a non-polypeptidic cardiac marker in said test sample, wherein said non-polypeptidic cardiac marker is selected from the group consisting of:
- sphingolipid, sphingosine, sphingosine-1-phosphate, dihydrosphingosine, sphingosylphosphorylcholine, and n-steroyl sphingosine.
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Abstract
The invention relates to methods, compositions, kits, and devices for detecting cardiac ischemia, hypoxia, or other causes of heart failure in a mammal by obtaining a test sample from a mammal, measuring a level of a non-polypeptidic cardiac marker in the test sample, and determining if the level of the cardiac marker measured in said test sample correlates with cardiac ischemia or hypoxia or another form of heart failure.
204 Citations
28 Claims
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1. Composition for detecting at least one non-polypeptidic cardiac marker in a test sample obtained from a mammal, said composition comprising at least one moiety that specifically binds a non-polypeptidic cardiac marker in said test sample, wherein said non-polypeptidic cardiac marker is selected from the group consisting of:
- sphingolipid, sphingosine, sphingosine-1-phosphate, dihydrosphingosine, sphingosylphosphorylcholine, and n-steroyl sphingosine.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
Specification