Method and apparatus for targeting material delivery to tissue
First Claim
Patent Images
1. A method for the interactive simulation of the movement of a first material in an organism, comprising:
- (a) constructing a field of local physical quantities appropriate to motion, appearance and disappearance of said material in said organism, and (b) constructing a field of a rate at which fluid flowing in said organism as a consequence of bodily processes or of an injection process moves at each position, thereby transporting said material, and (c) constructing a model of a source from which said material enters said organism, with any pressure differential or flux rate that causes it to enter said organism, and (d) computing a concentration field over time of said material, assuming a planned time course of said pressure differential or flux rate, and (e) using said concentration field to implement control of concentration of said material by adjustment of the source from which said material enters said organism.
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Abstract
Movement of material in an organism, such as a drug injected into a brain, is modeled by a uniformly structured field of static constants governing transport by moving fluid and diffusion within the fluid. This supports planning of material introduction, (e.g., infusion, perfusion, retroperfusion, injections, etc.) to achieve a desired distribution of the material, continuing real-time feedback as to whether imaged material is moving as planned and will be distributed as desired, and real-time plan modification to improve results.
130 Citations
32 Claims
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1. A method for the interactive simulation of the movement of a first material in an organism, comprising:
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(a) constructing a field of local physical quantities appropriate to motion, appearance and disappearance of said material in said organism, and (b) constructing a field of a rate at which fluid flowing in said organism as a consequence of bodily processes or of an injection process moves at each position, thereby transporting said material, and (c) constructing a model of a source from which said material enters said organism, with any pressure differential or flux rate that causes it to enter said organism, and (d) computing a concentration field over time of said material, assuming a planned time course of said pressure differential or flux rate, and (e) using said concentration field to implement control of concentration of said material by adjustment of the source from which said material enters said organism. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A method for the interactive simulation of the movement of a first material in an organism, comprising:
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(a) constructing a field of local physical quantities appropriate to motion, appearance and disappearance of said material in said organism, and (b) constructing a field of a rate at which fluid flowing in said organism as a consequence of bodily processes or of an injection process moves at each position, thereby transporting said material, and (c) constructing a model of a source from which said material enters said organism, with any pressure differential or flux rate that causes it to enter said organism, and (d) computing a concentration field over time of said material, assuming a planned time course of said pressure differential or flux rate, and (e) using said concentration field to implement control of concentration of said material by adjustment of the source from which said material enters said organism, where the field of local physical quantities is constructed from magnetic resonance data that, by appropriate scaling or other physically calibrated transformation, imply values for concentrations and/or motions of a material that has physical, chemical and biological properties different from those of the first material to be predictive of its transport properties.
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31. A method for providing a plan for the introduction of a first material to the tissue of a patient comprising:
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providing an image of an interior volume of a patient, the image having more than one type of bodily composition within a field of view of the image, assigning or determining values for at least two of said more than one type of bodily composition within said field of view, said values relating to at least one property selected from the group consisting of a) solvating ability, b) diffusivity, c) absorptivity, d) adsorptivity, e) degradation, f) production and g) transmissivity for a class of compounds or a specific compound, selecting a position within the field of view for introduction of a first material, selecting a rate of introduction of the first material at said position, determining a pattern of movement over time of first material movement from said position based upon at least the rate of introduction and at least at least one property in said group, comparing said pattern of first material movement to objectives for providing said first material to tissue within said patient, and modifying at least one of a) said position, b) said rate of introduction, c) length of time of first material introduction, and d) physical properties of said first material.
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32. A method for providing a plan for the introduction of a first material to the tissue of a patient comprising:
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providing an image of an interior volume of a patient, the image having more than one type of bodily composition within a field of view of the image, assigning or determining values for at least two of said more than one type of bodily composition within said field of view, said values relating to at least one property selected from the group consisting of a) solvating ability, b) diffusivity, c) absorptivity, d) adsorptivity, and transmissivity for a class of compounds or a specific compound, selecting a position within the filed of view for introduction of a first material, selecting a rate of introduction of the first material at said position, determining a path of first material movement from said position based upon at least the rate of introduction and at least on of said at least one property, comparing said path of first material movement to objectives for providing said first material to tissue within said patient, and modifying at least one of a) said position, b) said rate of introduction, c) length of time of first material introduction, and d) physical properties of said first material.
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Specification