Iontophoretic delivery patch

• US 6,560,483 B1
• Filed: 10/18/2000
• Issued: 05/06/2003
• Est. Priority Date: 10/18/2000
• Status: Expired due to Term

• Current Assignee: Minnesota High Tech Resources LLC
• Original Assignee: Minnesota High Tech Resources LLC
• Inventors: Johnson, Larry D., Kumar, Matthew M.
• Primary Examiner(s): Look, Edward K.
• Assistant Examiner(s): McCoy, Kimya N
• Application Number:
  US09/691,312
• Time in Patent Office: 930 Days
• Field of Search: 604/20, 604/501, 604/500, 604/289, 604/890.1
• US Class Current: 604/20
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

A patch for iontophoretic transdermal application of a medicant, where the patch includes a border portion disposed about an aperture. The border portion can include a first polarity electrode in electrical communication with the medicant, and a second border portion including a second electrode having a second polarity opposite the first electrode polarity. One patch has a liftable cover, preferably a transparent and non-adherent cover, disposed over the patch aperture. A preferred medicant for inclusion in the present invention is a local anesthetic or analgesic. Other medicants such as anti-inflammatory agents or anti-infective agents may be used to locally reduce inflammation, contain infection, and alleviate pain. The present invention can allow performing a field block anesthetic about an epidermal target site. The present invention can allow observing a target or treatment site while leaving the patch in place. An invasive medical procedure can be performed through the patch aperture, and pre-operative and post-operative procedures can also be performed through the patch aperture.

Claims

1. A patch for transdermal application of a medicant comprising:

a patch border portion disposed about an aperture;

said border portion including a first polarity electrode disposed about said aperture and disposed to be in electrical communication with said medicant;

said border portion including a second electrode disposed about said aperture and having a polarity opposite said first electrode, said second electrode being electrically separated from said first electrode.

2. A patch for transdermal application of a medicant as in claim 1, further comprising a liftable portion disposed over said aperture.

3. A patch for transdermal application of a medicant as in claim 2, wherein said liftable portion is removable.

4. A patch for transdermal application of a medicant as in claim 2, wherein said liftable portion has a periphery and said liftable portion is attached to said patch border along at least one portion of said periphery.

5. A patch for transdermal application of a medicant as in claim 2, wherein said patch liftable portion is transparent.

6. A patch for transdermal application of a medicant as in claim 2, wherein said patch liftable portion is non-adherent to skin.

7. A patch for transdermal application of a medicant as in claim 2, wherein said patch border portion is contiguous.

8. A patch for transdermal application of a medicant as in claim 2, wherein said patch border portion includes non-contiguous border segments.

9. A patch for transdermal application of a medicant as in claim 2, wherein said medicant includes an analgesic.

10. A patch for transdermal application of a medicant as in claim 2, wherein said medicant includes an anesthetic.

11. A patch for transdermal application of a medicant as in claim 2, wherein said medicant includes at least one anti-inflammatory agent.

12. A patch for transdermal application of a medicant as in claim 2, wherein said medicant includes at least one anti-infective agent.

13. A patch for transdermal application of a medicant for use with a first electrode comprising:

a patch border portion disposed about an aperture;

said border portion including a patch electrode disposed about said aperture and disposed to be in electrical communication with said medicant.

14. A patch for transdermal application of a medicant as in claim 13, further comprising a liftable portion disposed over said aperture.

15. A patch for transdermal application of a medicant as in claim 13, wherein said liftable portion is removable.

16. A patch for transdermal application of a medicant as in claim 13, wherein said liftable portion has a periphery and said liftable portion is attached to said patch border along at least one portion of said periphery.

17. A patch for transdermal application of a medicant as in claim 13, wherein said patch liftable portion is transparent.

18. A patch for transdermal application of a medicant as in claim 13, wherein said patch liftable portion is non-adherent to skin.

19. A patch for transdermal application of a medicant as in claim 13, wherein said patch border portion is contiguous.

20. A patch for transdermal application of a medicant as in claim 13, wherein said patch border portion includes non-contiguous border segments.

21. A patch for transdermal application of a medicant as in claim 13, wherein said medicant includes an analgesic.

22. A patch for transdermal application of a medicant as in claim 13, wherein said medicant includes an anesthetic.

23. A patch for transdermal application of a medicant as in claim 13, wherein said medicant includes at least one anti-inflammatory agent.

24. A patch for transdermal application of a medicant as in claim 13, wherein said medicant includes at least one anti-infective agent.

25. A method for performing a field block anesthetic about an epidermal target site having a border region disposed about said target site, the method comprising the step of:

delivering an anesthetic substance in said border region while not delivering said anesthetic substance to said target site, and while not injecting said anesthetic substance under pressure into said epidermal border region.

26. A method for performing a field block anesthetic about an epidermal target site as in claim 25, wherein said anesthetic substance delivery step is accomplished without mechanically penetrating into said epidermal border region.

27. A method for performing a field block anesthetic about an epidermal target site as in claim 25, wherein said anesthetic substance delivery step is accomplished iontophoretically.

28. A method for performing a field block anesthetic about an epidermal target site having a border region disposed about said target site, the method comprising the step of:

iontophoretically delivering an anesthetic substance in said border region while not iontophoretically delivering said anesthetic substance to said target site.

29. A method for performing a field block anesthetic as in claim 28, further comprising observing said target site while delivering said anesthetic substance.

30. A method for performing a field block anesthetic as in claim 28, wherein said iontophoretically delivery step includes providing a liftable cover over said target site and lifting said liftable cover during said iontopheretic delivery step and observing said target site.

31. A method for performing a field block anesthetic as in claim 30, wherein said iontophoretically delivery step includes providing a non-adherent cover over said target site and lifting step does not include adhesively pulling of said target site.

32. A method for performing a field block anesthetic as in claim 28, wherein said iontophoretically delivery step includes providing a transparent cover over said target site and observing said target site during said iontophoretically delivery step.

33. A method for performing a field block anesthetic as in claim 28, wherein the method includes performing an invasive medical procedure on said target site during said iontophoretically delivery step.

34. A method for managing pain during an epidermally invasive procedure at an epidermal target site having a border region disposed about the target site, the method comprising the steps of:

performing an anesthetic field block by iontophoretically delivering an anesthetic substance in said border region while not iontophoretically delivering said anesthetic substance to said target site; and

performing said epidermally invasive procedure.

35. A method for managing pain as in claim 34, wherein said performing anesthetic field block step is performed before said epidermally invasive procedure step.

36. A method for managing pain as in claim 34, wherein said performing anesthetic field block step is performed after said epidermally invasive procedure step.

37. A method for managing pain as in claim 34, wherein said performing anesthetic field block step is performed both before and after said epidermally invasive procedure step.

38. A method for managing pain as in claim 34, wherein said epidermally invasive procedure step is selected from the group of procedures consisting of:

incisions, drainage, excisions, punctures, skin abrasions, mucus membrane abrasions, and deeper tissue anesthetic injections.

39. A method for managing inflammation at an inflamed epidermal target site having a border region disposed about the target site, the method comprising surrounding the inflamed site by iontophoretically delivering at least one anti-inflammatory agent.

40. A method for managing inflammation at an inflamed epidermal target site as in claim 39, wherein said at least one anti-inflammatory agent is selected from the group consisting of salicylates and corticosteroids.

41. A method for managing infection at an epidermal target site having a border region disposed about the target site, the method comprising surrounding the inflamed site by iontophoretically delivering at least one anti-infective agent.

42. A method for enhancing wound healing at an epidermal target site having a border region disposed about the target site, the method comprising surrounding the target site with electrical potential applied in said border region.

43. A method for performing a field block anesthetic about an epidermal target site having a border region disposed about said target site, the method comprising the step of:

actively delivering an anesthetic substance in said border region while not actively delivering said anesthetic substance to said target site, and while not injecting said anesthetic substance under pressure into said epidermal border region.