Solid carriers for improved delivery of hydrophobic active ingredients in pharmaceutical compositions

  • US 6,569,463 B2
  • Filed: 03/06/2001
  • Issued: 05/27/2003
  • Est. Priority Date: 11/23/1999
  • Status: Expired due to Term
First Claim
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1. A pharmaceutical composition in the form of a solid carrier comprising a substrate and an encapsulation coat on the substrate, wherein the encapsulation coat comprises an admixture of a therapeutically effective amount of a hydrophobic pharmaceutical active ingredient, an effective solubilizing amount of at least one hydrophilic surfactant, and a lipophilic additive selected from the group consisting of lipophilic surfactants, triglycerides, and combinations thereof, wherein the effective solubilizing amount of the at least one hydrophilic surfactant is an amount effective to partially or fully solubilize the pharmaceutical active ingredient in the encapsulation coat.

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