Genetic constructs for delaying or repressing the expression of a target gene

  • US 6,573,099 B2
  • Filed: 06/19/1998
  • Issued: 06/03/2003
  • Est. Priority Date: 03/20/1998
  • Status: Expired due to Term
First Claim
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1. An isolated genetic construct which is capable of delaying, repressing or otherwise reducing the expression of a target gene in an animal cell which is transfected with said genetic construct, wherein said genetic construct comprises at least two copies of a structural gene sequence, wherein said structural gene sequence comprises a nucleotide sequence which is substantially identical to at least a region of said target gene, and wherein said at least two copies of said structural gene sequence are placed operably under the control of a single promoter sequence which is operable in said cell, wherein at least one copy of said structural gene sequence is placed operably in the sense orientation under the control of said promoter sequence.

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