Device for automated detection of nucleic acids
First Claim
1. A device for the automated detection of at least two target nucleic acid sequences, said device comprising a pipette-like device having an internal and external surface and an internal cavity defined by said internal surface, wherein said internal surface is coated with at least two capture nucleic acid sequences which bind to said target nucleic acid sequences to form hybridization complexes, and wherein said target nucleic acids are discretely detected in said device.
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Abstract
The present invention relates to the detection of specific nucleic acid sequences after an amplification process, or directly without amplification. In particular, the invention provides for the automation of the amplification and detection process, the amplification and detection of one or more specific nucleic acid sequences, the use of internal controls, reduced potential for contamination caused by the manual manipulation of reagents, and improved reagent compositions to better control assay performance and provide for further protection against contamination.
128 Citations
11 Claims
- 1. A device for the automated detection of at least two target nucleic acid sequences, said device comprising a pipette-like device having an internal and external surface and an internal cavity defined by said internal surface, wherein said internal surface is coated with at least two capture nucleic acid sequences which bind to said target nucleic acid sequences to form hybridization complexes, and wherein said target nucleic acids are discretely detected in said device.
Specification