Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs

CAFC
  • US 6,586,458 B1
  • Filed: 04/27/2000
  • Issued: 07/01/2003
  • Est. Priority Date: 08/16/1996
  • Status: Expired due to Term
First Claim
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1. A method of treating a patient for migraine headache, comprising:

  • (a) administering a 5-HT agonist to said patient, wherein said 5-HT agonist is a triptan; and

    (b) administering a long-acting, non-steroidal, anti-inflammatory drug (LA-NSAID) to said patient, wherein said LA-NSAID has a pharmacokinetic half-life of at least 4 hours and a duration of action of at least 6 hours;

    wherein;

    (i) said 5-HT agonist and said LA-NSAID are concomitantly administered in unit dosage form; and

    (ii) the respective amounts of said 5-HT agonist and said LA-NSAID administered to said patient are sufficient to produce longer lasting efficacy compared to the administration of said 5-HT agonist in the absence of said LA-NSAID or the administration of said LA-NSAID in the absence of said 5-HT agonist.

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