Treatment of obesity by bilateral vagus nerve stimulation

• US 6,587,719 B1
• Filed: 07/01/1999
• Issued: 07/01/2003
• Est. Priority Date: 07/01/1999
• Status: Expired due to Term

• Current Assignee: Cyberonics, Inc
• Original Assignee: Cyberonics, Inc
• Inventors: Roslin, Mitchell S., Barrett, Burke, Reddy, Ramish K.
• Primary Examiner(s): Schaetzle, Kennedy
• Application Number:
  US09/346,396
• Time in Patent Office: 1,461 Days
• Field of Search: 607/2, 607/45, 607/58, 607/70, 607/72, 607/74
• US Class Current: 607/2
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/32 alternating or intermittent currents applying electric fields by inductive or capacitive coupling A61N1/40; microwave apparatus A61N5/02

Abstract

A method of treating patients for compulsive overeating includes stimulating left and right branches of the patient'"'"'s vagus nerve simultaneously with electrical pulses in a predetermined sequence of a first period in which pulses are applied continuously, alternating with a second period in which no pulses are applied. The electrical pulses are preferably applied to the vagus nerve at a supradiaphragmatic location.

Claims

1. A method of treating patients for obesity, which comprises the steps of:

performing bilateral stimulation of the patient'"'"'s vagus nerve by applying a stimulating electrical signal directly and intermittently to the right and left vagi, wherein the parameters of said signal are predetermined to produce a sensation of satiety in the patient.

2. The method of claim 1, including the step of applying said stimulating electrical signal intermittently to the right and left vagi during a customary mealtime according to the patients circadian cycle.

3. The method of claim 1, including the step of applying said stimulating electrical signal intermittently to the right and left vagi upon delivery of an external commencement signal administered by the patient.

4. The method of claim 1, including the step of applying the same stimulating electrical signal intermittently to both the right and left vagi.

5. The method of claim 1, including using separate nerve stimulator generators for intermittently stimulating the left and right vagi.

6. The method of claim 1, including the step of applying said stimulating electrical signal supra diaphragmatically to the left and right vagi.

7. The method of claim 1, wherein said stimulating electrical signal is characterized by a current magnitude below a predetermined retching level.

8. The method of claim 1, wherein said stimulating electrical signal is a pulse signal having a prescribed on-off duty cycle.

9. The method of claim 8, including the step of applying said stimulating electrical signal continuously to the right and left vagi so that pulses are applied during the on portion of said duty cycle and not during the off portion of said duty cycle.

10. The method of claim 9, including using separate nerve stimulator generators for stimulating the left and right vagi.

11. The method of claim 9, including the step of applying said stimulating electrical signal supra diaphragmatically to the left and right vagi.

12. The method of claim 9, wherein one of said parameters of said stimulating electrical signal is a pulse current magnitude below a predetermined level at which the signal tends to produce retching in the patient.

13. The method of claim 9, wherein said pulse signal has a pulse current magnitude in a range up to about 6 ma.

14. The method of claim 13, wherein said pulse signal has a pulse width in a range up to about 500 ms.

15. The method of claim 14, wherein said pulse signal has a repetition frequency of about 30 Hz.

16. The method of claim 15, wherein said pulse signal has a duty cycle with a ratio of on to off of about 1:

1.8.

17. The method of claim 1, wherein said electrical signal is applied synchronously to the right and left vagi.

18. A method of treating patients for obesity, which comprises the steps of:

bilaterally stimulating the patient'"'"'s vagus nerve by chronically applying a stimulating electrical signal intermittently to the right and left vagi, the parameters or said signal being selected to produce a sensation of satiety in the patient.

19. A method of treating patients for obesity, which comprises the steps of:

implanting separate nerve stimulator generators into the patient, and

bilaterally stimulating The patient'"'"'s vagus nerve by applying a stimulating electrical signal intermittently to the right and left vagi from said implanted separate nerve stimulator generators, the parameters of said signal being selected to produce a sensation of satiety in the patient.

20. A method of treating patients for obesity, which comprises the steps of:

implanting nerve stimulator generator apparatus into the patient, and

bilaterally stimulating the patient'"'"'s vagus nerve by applying a stimulating electrical signal intermittently to the right and left vagi from said implanted nerve stimulator generator apparatus, the parameters of said signal being selected to produce a sensation of satiety in the patient.

21. A method of treating patients for obesity, which comprises the steps of:

implanting separate nerve stimulator generators into the patient, and

bilaterally stimulating the patient'"'"'s vagus nerve by applying a stimulating electrical signal in the form of a pulse signal having a prescribed on-off duty cycle continuously to the right and left vagi from said implanted separate nerve stimulator generators, so that pulses are applied during the on portion of said duty cycle and not during the off portion of said duty cycle, the parameters of said signal being selected to produce a sensation of satiety in the patient.

22. A method of treating patients for compulsive overeating, which comprises the steps of:

directly stimulating the left and right branches of the patient'"'"'s vagus nerve simultaneously with electrical pulses in a predetermined sequence of a first period in which pulses are applied continuously, alternating with a second period in which no pulses are applied.

23. The method of claim 22, including the step of applying said electrical pulses to the vagus nerve at a supradiaphragmatic location.

24. The method of claim 23, wherein said pulses have an electrical current magnitude not exceeding about 6 ma.

25. The method of claim 24, wherein said electrical current magnitude is preselected to be less than a level that induces retching in the patient.

26. The method of claim 25, wherein said pulses have a width not exceeding about 500 ms.

27. The method of claim 26, wherein said pulses have a repetition frequency of about 30 Hz.

28. The method of claim 27, wherein said second period is 1.8 times as long as said first period.